Literature DB >> 15270692

BCG (Bacille Calmette-Guérin) HspCs (heat-shock protein-peptide complexes) induce T-helper 1 responses and protect against live challenge in a murine aerosol challenge model of pulmonary tuberculosis.

C A L S Colaco1, C R Bailey, J Keeble, K B Walker.   

Abstract

The need for an effective TB (tuberculosis) vaccine remains acute, with tuberculosis still one of the major killers worldwide and 3 million new infections annually. We report here on the immune responses elicited by HspCs (heat-shock protein-peptide complexes) isolated from BCG (Bacille Calmette-Guérin) vaccine. These HspCs elicit both the appropriate cellular and protective immune responses required to merit their further development as TB vaccine candidates.

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Year:  2004        PMID： 15270692     DOI： 10.1042/BST0320626

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  6 in total

1.  Activation of TRIF-dependent and independent immune responses by neisserial heat shock protein complex vaccines.

Authors:  Garrett Z Ng; Jia-Xi Han; Camilo A Colaco; Philip Sutton
Journal:  Hum Vaccin Immunother       Date:  2016-06-20       Impact factor: 3.452

2.  Evaluation of immuno-modulating effect of recombinant heat shock protein 40 of Brucella abortus in mice.

Authors:  Priyanka Minhas; B V Sunil Kumar; Ramneek Verma
Journal:  3 Biotech       Date:  2019-09-23       Impact factor: 2.406

Review 3.  Heat-shock proteins as dendritic cell-targeting vaccines--getting warmer.

Authors:  Shaun McNulty; Camilo A Colaco; Lucy E Blandford; Christopher R Bailey; Selene Baschieri; Stephen Todryk
Journal:  Immunology       Date:  2013-08       Impact factor: 7.397

4.  Heat shock proteins enriched-promastigotes of Leishmania major inducing Th2 immune response in BALB/c mice.

Authors:  Marzieh Holakuyee; Mehdi Mahdavi; Zuhair Mohammad Hassan; Mohsen Abolhassani
Journal:  Iran Biomed J       Date:  2012

5.  Biochemical characterization and evaluation of a Brugia malayi small heat shock protein as a vaccine against lymphatic filariasis.

Authors:  Gajalakshmi Dakshinamoorthy; Abhilash Kumble Samykutty; Gnanasekar Munirathinam; Gangadhar Bhaurao Shinde; Thomas Nutman; Maryada Venkatarami Reddy; Ramaswamy Kalyanasundaram
Journal:  PLoS One       Date:  2012-04-05       Impact factor: 3.240

Review 6.  Heat shock proteins: stimulators of innate and acquired immunity.

Authors:  Camilo A Colaco; Christopher R Bailey; K Barry Walker; James Keeble
Journal:  Biomed Res Int       Date:  2013-05-25       Impact factor: 3.411
  6 in total

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