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Literature DB >> 15269820

Extracellular regulation of TGF-beta activity in wound repair: growth factor latency as a sensor mechanism for injury.

Abstract

The transforming growth factor-beta (TGFbeta) family of growth factors are major regulators of wound repair, scar formation, and fibrosis. One of the prominent features of TGFbeta biology is the fact that this growth factor is secreted as a latent precursor, which may be directed to and stored at specific sites in the cellular microenvironment. Targeting and mobilization, and particularly extracellular activation of latent TGF-beta control the biological action of this growth factor. This review will focus on mechanisms of extracellular TGF-beta regulation relevant to and potentially operating in wound repair and scarring.

Entities: Disease Gene

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Year: 2004 PMID： 15269820 DOI： 10.1160/TH04-05-0324

Source DB: PubMed Journal: Thromb Haemost ISSN： 0340-6245 Impact factor: 5.249

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Cited

19 in total

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