Literature DB >> 1526960

A unifying concept for ion translocation by retinal proteins.

D Oesterhelt1, J Tittor, E Bamberg.   

Abstract

First, halorhodopsin is capable of pumping protons after illumination with green and blue light in the same direction as chloride. Second, mutated bacteriorhodopsin where the proton acceptor Asp85 and the proton donor Asp96 are replaced by Asn showed proton pump activity after illumination with blue light in the same direction as wildtype after green light illumination. These results can be explained by and are discussed in light of our new hypothesis: structural changes in either molecule lead to a change in ion affinity and accessibility for determining the vectoriality of the transport through the two proteins.

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Year:  1992        PMID： 1526960     DOI： 10.1007/bf00762676

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   2.945


  65 in total

1.  Light-induced changes of the pH gradient and the membrane potential in H. halobium.

Authors:  H Michel; D Oesterhelt
Journal:  FEBS Lett       Date:  1976-06-01       Impact factor: 4.124

2.  The primary structure of a halorhodopsin from Natronobacterium pharaonis. Structural, functional and evolutionary implications for bacterial rhodopsins and halorhodopsins.

Authors:  J K Lanyi; A Duschl; G W Hatfield; K May; D Oesterhelt
Journal:  J Biol Chem       Date:  1990-01-25       Impact factor: 5.157

3.  Anion-induced wavelength regulation of absorption maxima of Schiff bases of retinal.

Authors:  P E Blatz; J H Mohler; H V Navangul
Journal:  Biochemistry       Date:  1972-02-29       Impact factor: 3.162

4.  Light isomerizes the chromophore of bacteriorhodopsin.

Authors:  M Tsuda; M Glaccum; B Nelson; T G Ebrey
Journal:  Nature       Date:  1980-09-25       Impact factor: 49.962

5.  Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy.

Authors:  R Henderson; J M Baldwin; T A Ceska; F Zemlin; E Beckmann; K H Downing
Journal:  J Mol Biol       Date:  1990-06-20       Impact factor: 5.469

6.  Aspartic acid substitutions affect proton translocation by bacteriorhodopsin.

Authors:  T Mogi; L J Stern; T Marti; B H Chao; H G Khorana
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205

7.  Replacement of aspartic acid-96 by asparagine in bacteriorhodopsin slows both the decay of the M intermediate and the associated proton movement.

Authors:  M Holz; L A Drachev; T Mogi; H Otto; A D Kaulen; M P Heyn; V P Skulachev; H G Khorana
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205

8.  The photocycle of the chloride pump halorhodopsin. II: Quantum yields and a kinetic model.

Authors:  D Oesterhelt; P Hegemann; J Tittor
Journal:  EMBO J       Date:  1985-09       Impact factor: 11.598

9.  The photocycle of the chloride pump halorhodopsin. I: Azide-catalyzed deprotonation of the chromophore is a side reaction of photocycle intermediates inactivating the pump.

Authors:  P Hegemann; D Oesterbelt; M Steiner
Journal:  EMBO J       Date:  1985-09       Impact factor: 11.598

10.  A defective proton pump, point-mutated bacteriorhodopsin Asp96----Asn is fully reactivated by azide.

Authors:  J Tittor; C Soell; D Oesterhelt; H J Butt; E Bamberg
Journal:  EMBO J       Date:  1989-11       Impact factor: 11.598
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  56 in total

1.  Electrical-to-mechanical coupling in purple membranes: membrane as electrostrictive medium.

Authors:  P Kietis; M Vengris; L Valkunas
Journal:  Biophys J       Date:  2001-04       Impact factor: 4.033

2.  Unraveling photoexcited conformational changes of bacteriorhodopsin by time resolved electron paramagnetic resonance spectroscopy.

Authors:  T Rink; M Pfeiffer; D Oesterhelt; K Gerwert; H J Steinhoff
Journal:  Biophys J       Date:  2000-03       Impact factor: 4.033

3.  Properties of the stochastic energization-relaxation channel model for vectorial ion transport.

Authors:  E Muneyuki; T A Fukami
Journal:  Biophys J       Date:  2000-03       Impact factor: 4.033

4.  Molecular dynamics study of the nature and origin of retinal's twisted structure in bacteriorhodopsin.

Authors:  E Tajkhorshid; J Baudry; K Schulten; S Suhai
Journal:  Biophys J       Date:  2000-02       Impact factor: 4.033

5.  Time-resolved step-scan Fourier transform infrared spectroscopy reveals differences between early and late M intermediates of bacteriorhodopsin.

Authors:  C Rödig; I Chizhov; O Weidlich; F Siebert
Journal:  Biophys J       Date:  1999-05       Impact factor: 4.033

6.  Characterization of the proton-transporting photocycle of pharaonis halorhodopsin.

Authors:  A Kulcsár; G I Groma; J K Lanyi; G Váró
Journal:  Biophys J       Date:  2000-11       Impact factor: 4.033

Review 7.  Pathways of proton transfer in the light-driven pump bacteriorhodopsin.

Authors:  J K Lanyi
Journal:  Experientia       Date:  1993-07-05

8.  Characterization of the azide-dependent bacteriorhodopsin-like photocycle of salinarum halorhodopsin.

Authors:  Melinda Lakatos; Géza I Groma; Constanta Ganea; Janos K Lanyi; György Váró
Journal:  Biophys J       Date:  2002-04       Impact factor: 4.033

Review 9.  Proton transfer and energy coupling in the bacteriorhodopsin photocycle.

Authors:  J K Lanyi
Journal:  J Bioenerg Biomembr       Date:  1992-04       Impact factor: 2.945

10.  The transducer protein HtrII modulates the lifetimes of sensory rhodopsin II photointermediates.

Authors:  J Sasaki; J L Spudich
Journal:  Biophys J       Date:  1998-11       Impact factor: 4.033
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