| Literature DB >> 15267231 |
Frédéric Bihel1, Chittaranjan Das, Michael J Bowman, Michael S Wolfe.
Abstract
Gamma-secretase is the second of two proteolytic enzymes responsible for the release of the amyloid beta-peptide implicated in the etiology of Alzheimer's disease. Here, we used solid-phase synthesis to generate a new series of helical peptides as gamma-secretase inhibitors, one of which, 11, showed an IC(50) of 140 pM in a cell-free enzyme assay.Entities:
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Year: 2004 PMID： 15267231 DOI： 10.1021/jm049788c
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446