Literature DB >> 15267120

Fluconazole resistance in Candida albicans: a review of mechanisms.

I A Casalinuovo1, P Di Francesco, E Garaci.   

Abstract

Antifungal agents have greatly contributed to the improvement of public health. Nevertheless, antifungal resistant pathogens have increased during the past decade, becoming a serious concern. Candida albicans has been the most extensively studied pathogen in antifungal resistance because of their morbidity and mortality associated with infections in immunocompromised patients. This review describes the antifungal mechanims of the azole fluconazole widely used for the prophylaxis and treatment of candidal infections. The specific molecular pathways occurring in fluconazole-resistance of C. albicans and some issues about new antifungal agents are also discussed.

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Year:  2004        PMID： 15267120

Source DB:  PubMed          Journal:  Eur Rev Med Pharmacol Sci        ISSN： 1128-3602            Impact factor:   3.507


  23 in total

Review 1.  Milestones in Candida albicans gene manipulation.

Authors:  Dhanushki P Samaranayake; Steven D Hanes
Journal:  Fungal Genet Biol       Date:  2011-04-14       Impact factor: 3.495

2.  Regulatory Role of ERG3 and Efg1 in Azoles-Resistant Strains of Candida albicans Isolated from Patients Diagnosed with Vulvovaginal Candidiasis.

Authors:  Wenli Feng; Jing Yang; Zhiqin Xi; Ying Ji; Xin Zhu; Lu Yang; Yan Ma
Journal:  Indian J Microbiol       Date:  2019-11-02       Impact factor: 2.461

Review 3.  Mechanisms of Antifungal Drug Resistance.

Authors:  Leah E Cowen; Dominique Sanglard; Susan J Howard; P David Rogers; David S Perlin
Journal:  Cold Spring Harb Perspect Med       Date:  2014-11-10       Impact factor: 6.915

4.  Mechanisms of azole resistance in a clinical isolate of Candida tropicalis.

Authors:  Patrick Vandeputte; Gérald Larcher; Thierry Bergès; Gilles Renier; Dominique Chabasse; Jean-Philippe Bouchara
Journal:  Antimicrob Agents Chemother       Date:  2005-11       Impact factor: 5.191

5.  Candida albicans Infection Model in Zebrafish (Danio rerio) for Screening Anticandidal Drugs.

Authors:  D C M Kulatunga; S H S Dananjaya; Chamilani Nikapitiya; Cheol-Hee Kim; Jehee Lee; Mahanama De Zoysa
Journal:  Mycopathologia       Date:  2019-08-31       Impact factor: 2.574

6.  Invitro Anti-mycotic Activity of Hydro Alcoholic Extracts of Some Indian Medicinal Plants against Fluconazole Resistant Candida albicans.

Authors:  Saranya Varadarajan; Malathi Narasimhan; Malaiyandi Malaisamy; Chamundeeswari Duraipandian
Journal:  J Clin Diagn Res       Date:  2015-08-01

7.  The structure of the Candida albicans Ess1 prolyl isomerase reveals a well-ordered linker that restricts domain mobility.

Authors:  Zhong Li; Hongmin Li; Gina Devasahayam; Trent Gemmill; Vishnu Chaturvedi; Steven D Hanes; Patrick Van Roey
Journal:  Biochemistry       Date:  2005-04-26       Impact factor: 3.162

8.  Dynamic interaction between fluconazole and amphotericin B against Cryptococcus gattii.

Authors:  Julliana Ribeiro Alves Santos; Ludmila Ferreira Gouveia; Erika Linzi Silva Taylor; Maria Aparecida Resende-Stoianoff; Gerson Antônio Pianetti; Isabela Costa César; Daniel Assis Santos
Journal:  Antimicrob Agents Chemother       Date:  2012-01-30       Impact factor: 5.191

9.  Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species.

Authors:  Maurizio Sanguinetti; Stefania Sanfilippo; Daniele Castagnolo; Dominique Sanglard; Brunella Posteraro; Giovanni Donzellini; Maurizio Botta
Journal:  ACS Med Chem Lett       Date:  2013-07-22       Impact factor: 4.345

10.  Candida albicans flu1-mediated efflux of salivary histatin 5 reduces its cytosolic concentration and fungicidal activity.

Authors:  Rui Li; Rohitashw Kumar; Swetha Tati; Sumant Puri; Mira Edgerton
Journal:  Antimicrob Agents Chemother       Date:  2013-02-04       Impact factor: 5.191
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