Literature DB >> 152655

An inhibitor from placenta specifically binds urokinase and inhibits plasminogen activator released from ovarian carcinoma in tissue culture.

L Holmberg, I Lecander, B Persson, B Astedt.   

Abstract

An inhibitor present in placenta and released in placental tissue culture forms specific complexes with each of two molecular forms of urokinase. Autoradiography demonstrated that the inhibitor shifted the electrophoretic position of 125I-labelled urokinase. It did not change the migration of diisopropyl-fluorophosphate-inactivated 125I-labelled urokinase, thereby indicating complex formation dependent on active serine site in urokinase. The inhibitor had a strong neutralizing effect on the plasminogen activators released from human ovarian carcinoma in tissue culture. The placental inhibitor might prove useful in inhibiting the fibrinolytic process necessary for proliferation of tumour vessels.

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Year:  1978        PMID： 152655     DOI： 10.1016/0304-4165(78)90216-7

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  12 in total

1.  Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells.

Authors:  B S Knudsen; P C Harpel; R L Nachman
Journal:  J Clin Invest       Date:  1987-10       Impact factor: 14.808

2.  Increased levels of plasminogen activator inhibitor-1 (PAI-1) in human brain tumors.

Authors:  J S Rao; A Rayford; R A Morantz; B W Festoff; R Sawaya
Journal:  J Neurooncol       Date:  1993-09       Impact factor: 4.130

3.  Immunological characterisation of plasminogen activators in the human vessel wall.

Authors:  H Ljungnér; L Holmberg; A Kjeldgaard; I M Nilsson; B Astedt
Journal:  J Clin Pathol       Date:  1983-09       Impact factor: 3.411

4.  Partial purification and characterization of a new fast-acting plasmin inhibitor from human platelets. Evidence for non-identity with the known plasma proteinase inhibitors.

Authors:  M Sandbjerg Hansen; I Clemmensen
Journal:  Biochem J       Date:  1980-04-01       Impact factor: 3.857

5.  Plasminogen activator and protease inhibitor activities in isolated rat thymocytes.

Authors:  M Mayer; Z Finci; J Kanaany; N Kaiser
Journal:  Mol Cell Biochem       Date:  1985-03       Impact factor: 3.396

6.  Two different mechanisms in patients with venous thrombosis and defective fibrinolysis: low concentration of plasminogen activator or increased concentration of plasminogen activator inhibitor.

Authors:  I M Nilsson; H Ljungnér; L Tengborn
Journal:  Br Med J (Clin Res Ed)       Date:  1985-05-18

7.  Immunohistochemical localisation of tissue plasminogen activator and urokinase in the vessel wall.

Authors:  A Larsson; B Astedt
Journal:  J Clin Pathol       Date:  1985-02       Impact factor: 3.411

Review 8.  The use of glycylhistidyllysine in culture systems.

Authors:  L Pickart
Journal:  In Vitro       Date:  1981-06

9.  A fast-acting elastase inhibitor in human monocytes.

Authors:  E Remold-O'Donnell
Journal:  J Exp Med       Date:  1985-12-01       Impact factor: 14.307

10.  Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells.

Authors:  J Pöllänen; O Saksela; E M Salonen; P Andreasen; L Nielsen; K Danø; A Vaheri
Journal:  J Cell Biol       Date:  1987-04       Impact factor: 10.539
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