BACKGROUND: Little is known about the role of inherited genotypes in prostate cancer (PC) progression. This prospective study evaluated the predictive value of androgen receptor (AR) polymorphisms (CAG and GGC repeats) among prostatectomy patients. METHODS: We studied 354 patients registered at M. D. Anderson Cancer Center from 1991 to 2001. Kaplan-Meier and Cox proportional hazard analyses were used. RESULTS: During an average follow-up of 56 months, 66 (19%) post-prostatectomy patients experienced biochemical failure (BF). Patients with higher CAG repeats (CAG > or = 24) had significantly longer BF-free survival (BFFS) than those with fewer repeats (CAG < or = 23) (P = 0.04). Higher CAG repeats were significantly associated with lower BF risk among Whites and African Americans. Among Whites, longer CAG repeats (relative risk (RR) = 0.45, P = 0.03) and Gleason score > or = 8 (RR = 19.33, P = 0.005) remained significant BFFS predictors in multivariate analysis. GGC repeats were not associated with BF. CONCLUSIONS: Our data showed that an inherited polymorphism (CAG repeats) in the AR is related to differences in genetic susceptibility to BF, supporting the hypothesis that increased AR activity may play a role in PC progression.
BACKGROUND: Little is known about the role of inherited genotypes in prostate cancer (PC) progression. This prospective study evaluated the predictive value of androgen receptor (AR) polymorphisms (CAG and GGC repeats) among prostatectomy patients. METHODS: We studied 354 patients registered at M. D. Anderson Cancer Center from 1991 to 2001. Kaplan-Meier and Cox proportional hazard analyses were used. RESULTS: During an average follow-up of 56 months, 66 (19%) post-prostatectomy patients experienced biochemical failure (BF). Patients with higher CAG repeats (CAG > or = 24) had significantly longer BF-free survival (BFFS) than those with fewer repeats (CAG < or = 23) (P = 0.04). Higher CAG repeats were significantly associated with lower BF risk among Whites and African Americans. Among Whites, longer CAG repeats (relative risk (RR) = 0.45, P = 0.03) and Gleason score > or = 8 (RR = 19.33, P = 0.005) remained significant BFFS predictors in multivariate analysis. GGC repeats were not associated with BF. CONCLUSIONS: Our data showed that an inherited polymorphism (CAG repeats) in the AR is related to differences in genetic susceptibility to BF, supporting the hypothesis that increased AR activity may play a role in PC progression.
Authors: Jorge Blando; Tricia Moore; Stephen Hursting; Guiyu Jiang; Achinto Saha; Linda Beltran; Jianjun Shen; John Repass; Sara Strom; John DiGiovanni Journal: Cancer Prev Res (Phila) Date: 2011-09-27
Authors: Christopher A Haiman; Gary K Chen; William J Blot; Sara S Strom; Sonja I Berndt; Rick A Kittles; Benjamin A Rybicki; William B Isaacs; Sue A Ingles; Janet L Stanford; W Ryan Diver; John S Witte; Stephen J Chanock; Suzanne Kolb; Lisa B Signorello; Yuko Yamamura; Christine Neslund-Dudas; Michael J Thun; Adam Murphy; Graham Casey; Xin Sheng; Peggy Wan; Loreall C Pooler; Kristine R Monroe; Kevin M Waters; Loic Le Marchand; Laurence N Kolonel; Daniel O Stram; Brian E Henderson Journal: PLoS Genet Date: 2011-05-26 Impact factor: 5.917
Authors: Zhaohui Du; Hannah Hopp; Sue A Ingles; Chad Huff; Xin Sheng; Brandi Weaver; Mariana Stern; Thomas J Hoffmann; Esther M John; Stephen K Van Den Eeden; Sara Strom; Robin J Leach; Ian M Thompson; John S Witte; David V Conti; Christopher A Haiman Journal: Int J Cancer Date: 2019-07-03 Impact factor: 7.396