Literature DB >> 15262954

Expression of a functional secreted YopN-TyeA hybrid protein in Yersinia pestis is the result of a +1 translational frameshift event.

Franco Ferracci1, James B Day, Heather J Ezelle, Gregory V Plano.   

Abstract

YopN is a secreted protein that prior to secretion directly interacts with the cytosolic SycN/YscB chaperone complex and TyeA. This study identifies a secreted YopN-TyeA hybrid protein that is expressed by Yersinia pestis, but not by Yersinia enterocolitica. DNA sequence analysis and site-directed mutagenesis studies demonstrate that the hybrid protein is the result of a +1 translational frameshift event.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15262954      PMCID： PMC451632          DOI： 10.1128/JB.186.15.5160-5166.2004

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  36 in total

1.  Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector.

Authors:  K Orth; L E Palmer; Z Q Bao; S Stewart; A E Rudolph; J B Bliska; J E Dixon
Journal:  Science       Date:  1999-09-17       Impact factor: 47.728

Review 2.  Molecular and cell biology aspects of plague.

Authors:  G R Cornelis
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

3.  Identification of SycN, YscX, and YscY, three new elements of the Yersinia yop virulon.

Authors:  M Iriarte; G R Cornelis
Journal:  J Bacteriol       Date:  1999-01       Impact factor: 3.490

4.  Yersinia enterocolitica TyeA, an intracellular regulator of the type III machinery, is required for specific targeting of YopE, YopH, YopM, and YopN into the cytosol of eukaryotic cells.

Authors:  L W Cheng; O Schneewind
Journal:  J Bacteriol       Date:  2000-06       Impact factor: 3.490

5.  A complex composed of SycN and YscB functions as a specific chaperone for YopN in Yersinia pestis.

Authors:  J B Day; G V Plano
Journal:  Mol Microbiol       Date:  1998-11       Impact factor: 3.501

6.  Modulation of host immune responses, induction of apoptosis and inhibition of NF-kappaB activation by the Bordetella type III secretion system.

Authors:  M H Yuk; E T Harvill; P A Cotter; J F Miller
Journal:  Mol Microbiol       Date:  2000-03       Impact factor: 3.501

7.  The Yersinia pestis YscY protein directly binds YscX, a secreted component of the type III secretion machinery.

Authors:  J B Day; G V Plano
Journal:  J Bacteriol       Date:  2000-04       Impact factor: 3.490

8.  Analyses of frameshifting at UUU-pyrimidine sites.

Authors:  R Schwartz; J F Curran
Journal:  Nucleic Acids Res       Date:  1997-05-15       Impact factor: 16.971

9.  The yopJ locus is required for Yersinia-mediated inhibition of NF-kappaB activation and cytokine expression: YopJ contains a eukaryotic SH2-like domain that is essential for its repressive activity.

Authors:  K Schesser; A K Spiik; J M Dukuzumuremyi; M F Neurath; S Pettersson; H Wolf-Watz
Journal:  Mol Microbiol       Date:  1998-06       Impact factor: 3.501

10.  DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of Yersinia pestis KIM5.

Authors:  R D Perry; S C Straley; J D Fetherston; D J Rose; J Gregor; F R Blattner
Journal:  Infect Immun       Date:  1998-10       Impact factor: 3.441
View more
  15 in total

1.  Measurement of effector protein injection by type III and type IV secretion systems by using a 13-residue phosphorylatable glycogen synthase kinase tag.

Authors:  Julie Torruellas Garcia; Franco Ferracci; Michael W Jackson; Sabrina S Joseph; Isabelle Pattis; Lisa R W Plano; Wolfgang Fischer; Gregory V Plano
Journal:  Infect Immun       Date:  2006-10       Impact factor: 3.441

Review 2.  Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.

Authors:  John F Atkins; Gary Loughran; Pramod R Bhatt; Andrew E Firth; Pavel V Baranov
Journal:  Nucleic Acids Res       Date:  2016-07-19       Impact factor: 16.971

3.  Yersinia pestis uses the Ail outer membrane protein to recruit vitronectin.

Authors:  Sara Schesser Bartra; Yi Ding; L Miya Fujimoto; Joshua G Ring; Vishal Jain; Sanjay Ram; Francesca M Marassi; Gregory V Plano
Journal:  Microbiology (Reading)       Date:  2015-09-15       Impact factor: 2.777

4.  Identification and functional analysis of CT069 as a novel transcriptional regulator in Chlamydia.

Authors:  Johnny C Akers; HoangMinh HoDac; Richard H Lathrop; Ming Tan
Journal:  J Bacteriol       Date:  2011-09-09       Impact factor: 3.490

5.  YopK controls both rate and fidelity of Yop translocation.

Authors:  Rebecca Dewoody; Peter M Merritt; Melanie M Marketon
Journal:  Mol Microbiol       Date:  2012-12-04       Impact factor: 3.501

Review 6.  Timing is everything: the regulation of type III secretion.

Authors:  Janet E Deane; Patrizia Abrusci; Steven Johnson; Susan M Lea
Journal:  Cell Mol Life Sci       Date:  2009-12-31       Impact factor: 9.261

7.  Structures of the Shigella flexneri type 3 secretion system protein MxiC reveal conformational variability amongst homologues.

Authors:  Janet E Deane; Pietro Roversi; Carole King; Steven Johnson; Susan M Lea
Journal:  J Mol Biol       Date:  2008-02-04       Impact factor: 5.469

Review 8.  Regulation of the Yersinia type III secretion system: traffic control.

Authors:  Rebecca S Dewoody; Peter M Merritt; Melanie M Marketon
Journal:  Front Cell Infect Microbiol       Date:  2013-02-06       Impact factor: 5.293

9.  The SycN/YscB chaperone-binding domain of YopN is required for the calcium-dependent regulation of Yop secretion by Yersinia pestis.

Authors:  Sabrina S Joseph; Gregory V Plano
Journal:  Front Cell Infect Microbiol       Date:  2013-01-24       Impact factor: 5.293

10.  Bioinformatics analysis of the locus for enterocyte effacement provides novel insights into type-III secretion.

Authors:  Mark J Pallen; Scott A Beatson; Christopher M Bailey
Journal:  BMC Microbiol       Date:  2005-03-09       Impact factor: 3.605
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.