| Literature DB >> 15262537 |
Laura Garuti1, Marinella Roberti, Daniela Pizzirani, Annalisa Pession, Emanuela Leoncini, Valentina Cenci, Silvana Hrelia.
Abstract
Ten benzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Several compounds showed a significant antiproliferative activity on K562 cells, although to a different extent, whereas compound 1i showed a highly significant activity on SW620 cells, comparable to that of doxorubicin. Both the substituents in the quinone ring and the position of the nitrogen atom in the pyridine moiety play a crucial role for the biological activity.Entities:
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Year: 2004 PMID： 15262537 DOI： 10.1016/j.farmac.2004.04.001
Source DB: PubMed Journal: Farmaco ISSN： 0014-827X