| Literature DB >> 15261893 |
Uli C Broedl1, Weijun Jin, Daniel J Rader.
Abstract
Both acute and chronic inflammatory states are associated with decreased levels of high-density lipoprotein (HDL) cholesterol, yet the underlying mechanism is poorly understood. Endothelial lipase (EL), a recently described member of the triglyceride lipase family, has been shown to be a key enzyme in HDL metabolism. Expression of EL by endothelial cells is upregulated by proinflammatory cytokines and is associated with increased EL-specific triglyceride and phospholipase activity in vitro. Thus, EL may play an important role in lipid metabolism and energy homeostasis in states of acute and chronic inflammation.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15261893 DOI： 10.1016/j.tcm.2004.03.003
Source DB: PubMed Journal: Trends Cardiovasc Med ISSN： 1050-1738 Impact factor: 6.677