| Literature DB >> 15261831 |
Sébastien Mella1, Cathy Soula, Dominique Morello, Michèle Crozatier, Alain Vincent.
Abstract
The COE (Collier/Olf/EBF) family of transcription factors comprises a single member in Drosophila and four members in human and mice. We have examined by in situ hybridization the expression patterns of each ebf/coe gene during limb development in mouse and chicken embryos. Expression of mouse ebf1, 2 and 3 is detected in mesenchymal cells from stages E10.5-11, expression of ebf2 being restricted to the presumptive zeugopod. Cross sections of mouse and chicken limb buds at several stages reveal that ebfs are specifically expressed in the connective tissues surrounding chondrogenic condensations and forming tendons. They thus represent useful new markers for studying vertebrate limb development, particularly formation of ligaments.Entities:
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Year: 2004 PMID： 15261831 DOI： 10.1016/j.modgep.2004.02.005
Source DB: PubMed Journal: Gene Expr Patterns ISSN： 1567-133X Impact factor: 1.224