| Literature DB >> 15261341 |
Ann Marshak-Rothstein1, Liliana Busconi, Ian R Rifkin, Gregory A Viglianti.
Abstract
As immunologists have long understood, effective responses to foreign antigens require adjuvants. It is now apparent that the initiation of autoimmune disease is comparably facilitated by adjuvant activity. In the case of antinuclear antibodies, it seems that DNA itself can serve as an endogenous adjuvant. Similar to many of the microbial adjuvants, mammalian DNA mediates its effect through a Toll-like receptor--in this case, TLR9.Entities:
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Year: 2004 PMID： 15261341 DOI： 10.1016/j.rdc.2004.04.005
Source DB: PubMed Journal: Rheum Dis Clin North Am ISSN： 0889-857X Impact factor: 2.670