| Literature DB >> 15261286 |
Ming-Zhe Xu1, Woo Song Lee, Mi Jeong Kim, Doo-Sang Park, Hana Yu, Guan-Rong Tian, Tae-Sook Jeong, Ho-Yong Park.
Abstract
Unsaturated fatty acid amides, 9(Z)-octadecenamide (2) and 9(Z),12(Z)-octadecadienamide (4) as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT) were isolated from the ethyl acetate extracts of the insect, Mylabris phalerate Pallas, and elucidated by their spectroscopic data analysis. Compounds 2 and 4 inhibited rat liver microsomal ACAT, hACAT-1, and hACAT-2 with IC(50) values of 170, 85, and 63 microM for 2 and of 151, 53, and 45 microM for 4, respectively.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15261286 DOI： 10.1016/j.bmcl.2004.05.086
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823