| Literature DB >> 15261264 |
J T Link1, Bryan K Sorensen, Jyoti Patel, David Arendsen, Gaoquan Li, Susan Swanson, Bach Nguyen, Maurice Emery, Marlena Grynfarb, Annika Goos-Nilsson.
Abstract
The optimization of a series of nonsteroidal glucocorticoid modulators is reported. Potent selective GR ligands that have improved metabolic stability were discovered typified by the subnanomolar acid 12 (GR binding IC(50)=0.6 nM).Mesh：
Substances：
Year: 2004 PMID： 15261264 DOI： 10.1016/j.bmcl.2004.06.023
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823