Literature DB >> 15261261

Thiourea inhibitors of herpesviruses. Part 3: Inhibitors of varicella zoster virus.

Martin J Di Grandi1, Kevin J Curran, Gregg Feigelson, Amar Prashad, Adma A Ross, Robert Visalli, Jeanette Fairhurst, Boris Feld, Jonathan D Bloom.   

Abstract

The preparation of alpha-methylbenzyl thioureas and their biological activity against varicella zoster virus is described. Several analogs demonstrated IC50s<0.1 microM and their SAR are discussed. These compounds represent a novel class of potent and selective nonnucleoside inhibitors of varicella zoster virus.

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Year:  2004        PMID： 15261261     DOI： 10.1016/j.bmcl.2004.06.025

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  High pressure liquid chromatographic analysis of in vivo metabolites of N-(substituted phenyl)-N'-(1,3,5-trimethyl pyrazole-4-yl)thioureas in rats.

Authors:  Bedia Kocyigit-Kaymakcioglu; Ufuk Yilmaz; Feyza Aricioglu
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2007 Oct-Dec       Impact factor: 2.441

2.  The Varicella-zoster virus ORF54 gene product encodes the capsid portal protein, pORF54.

Authors:  Alexander J Howard; Debra M Sherman; Melissa A Visalli; Denise M Burnside; Robert J Visalli
Journal:  Virus Res       Date:  2012-03-28       Impact factor: 3.303

3.  The Varicella-zoster virus DNA encapsidation genes: Identification and characterization of the putative terminase subunits.

Authors:  Robert J Visalli; Denise M Nicolosi; Karen L Irven; Bradley Goshorn; Tamseel Khan; Melissa A Visalli
Journal:  Virus Res       Date:  2007-09-14       Impact factor: 3.303

4.  Characterization of the Varicella-zoster virus ORF25 gene product: pORF25 interacts with multiple DNA encapsidation proteins.

Authors:  Robert J Visalli; Jacquelyn Knepper; Bradley Goshorn; Katherine Vanover; Denise M Burnside; Karen Irven; Rebecca McGauley; Melissa Visalli
Journal:  Virus Res       Date:  2009-04-07       Impact factor: 3.303

5.  1-[(Ferrocen-1-yl)meth-yl]-3-(naphthalen-1-yl)thio-urea.

Authors:  Xia Li; Wei Liu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-11-12

6.  Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor.

Authors:  Simona Musella; Veronica di Sarno; Tania Ciaglia; Marina Sala; Antonia Spensiero; Maria Carmina Scala; Carmine Ostacolo; Graciela Andrei; Jan Balzarini; Robert Snoeck; Ettore Novellino; Pietro Campiglia; Alessia Bertamino; Isabel M Gomez-Monterrey
Journal:  Eur J Med Chem       Date:  2016-09-07       Impact factor: 6.514

7.  Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion.

Authors:  Yuhang Liu; Kyle P Heim; Ye Che; Xiaoyuan Chi; Xiayang Qiu; Seungil Han; Philip R Dormitzer; Xinzhen Yang
Journal:  Sci Adv       Date:  2021-03-05       Impact factor: 14.136

8.  Investigation of the reactivity properties of a thiourea derivative with anticancer activity by DFT and MD simulations.

Authors:  Y Sheena Mary; Y Shyma Mary; Anna Bielenica; Stevan Armaković; Sanja J Armaković; Vivek Chandramohan; Manjunath Dammalli
Journal:  J Mol Model       Date:  2021-07-03       Impact factor: 1.810
  8 in total

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