| Literature DB >> 15260983 |
Robert H Insall1, Laura M Machesky.
Abstract
Cdc42 is a key regulator of cell polarity and actin dynamics. One of its effectors, WASP, initiates the assembly of new actin filaments. In this issue of Cell, show that a previously unknown regulator named Toca-1 is required for Cdc42 to activate WASP. This discovery changes our picture of how small GTPases and multiple other signals converge to stimulate actin polymerization and cell motility.Entities:
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Year: 2004 PMID： 15260983 DOI： 10.1016/j.cell.2004.07.005
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582