Literature DB >> 15258571

Clostridium perfringens epsilon-toxin shows structural similarity to the pore-forming toxin aerolysin.

Ambrose R Cole1, Maryse Gibert, Michel Popoff, David S Moss, Richard W Titball, Ajit K Basak.   

Abstract

Epsilon-toxin from Clostridium perfringens is a lethal toxin. Recent studies suggest that the toxin acts via an unusually potent pore-forming mechanism. Here we report the crystal structure of epsilon-toxin, which reveals structural similarity to aerolysin from Aeromonas hydrophila. Pore-forming toxins can change conformation between soluble and transmembrane states. By comparing the two toxins, we have identified regions important for this transformation.

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Year:  2004        PMID： 15258571     DOI： 10.1038/nsmb804

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  75 in total

1.  A Bayesian inference scheme to extract diffusivity and potential fields from confined single-molecule trajectories.

Authors:  Silvan Türkcan; Antigoni Alexandrou; Jean-Baptiste Masson
Journal:  Biophys J       Date:  2012-05-15       Impact factor: 4.033

2.  Observing the confinement potential of bacterial pore-forming toxin receptors inside rafts with nonblinking Eu(3+)-doped oxide nanoparticles.

Authors:  Silvan Türkcan; Jean-Baptiste Masson; Didier Casanova; Geneviève Mialon; Thierry Gacoin; Jean-Pierre Boilot; Michel R Popoff; Antigoni Alexandrou
Journal:  Biophys J       Date:  2012-05-15       Impact factor: 4.033

Review 3.  Pore-forming toxins: ancient, but never really out of fashion.

Authors:  Matteo Dal Peraro; F Gisou van der Goot
Journal:  Nat Rev Microbiol       Date:  2015-12-07       Impact factor: 60.633

4.  Clostridium perfringens epsilon-toxin increases permeability of single perfused microvessels of rat mesentery.

Authors:  R H Adamson; J C Ly; M Fernandez-Miyakawa; S Ochi; J Sakurai; F Uzal; F E Curry
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

5.  A rivet model for channel formation by aerolysin-like pore-forming toxins.

Authors:  Ioan Iacovache; Patrick Paumard; Holger Scheib; Claire Lesieur; Naomi Sakai; Stefan Matile; Michael W Parker; F Gisou van der Goot
Journal:  EMBO J       Date:  2006-01-19       Impact factor: 11.598

6.  Receptor displacement in the cell membrane by hydrodynamic force amplification through nanoparticles.

Authors:  Silvan Türkcan; Maximilian U Richly; Cedric I Bouzigues; Jean-Marc Allain; Antigoni Alexandrou
Journal:  Biophys J       Date:  2013-07-02       Impact factor: 4.033

Review 7.  Role of pore-forming toxins in bacterial infectious diseases.

Authors:  Ferdinand C O Los; Tara M Randis; Raffi V Aroian; Adam J Ratner
Journal:  Microbiol Mol Biol Rev       Date:  2013-06       Impact factor: 11.056

Review 8.  Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease.

Authors:  Francisco A Uzal; John C Freedman; Archana Shrestha; James R Theoret; Jorge Garcia; Milena M Awad; Vicki Adams; Robert J Moore; Julian I Rood; Bruce A McClane
Journal:  Future Microbiol       Date:  2014       Impact factor: 3.165

9.  Identification of Small Molecule Inhibitors of Clostridium perfringens ε-Toxin Cytotoxicity Using a Cell-Based High-Throughput Screen.

Authors:  Michelle Lewis; Charles David Weaver; Mark S McClain
Journal:  Toxins (Basel)       Date:  2010-07-01       Impact factor: 5.075

10.  Clostridium perfringens epsilon toxin targets granule cells in the mouse cerebellum and stimulates glutamate release.

Authors:  Etienne Lonchamp; Jean-Luc Dupont; Laetitia Wioland; Raphaël Courjaret; Corinne Mbebi-Liegeois; Emmanuel Jover; Frédéric Doussau; Michel R Popoff; Jean-Louis Bossu; Jean de Barry; Bernard Poulain
Journal:  PLoS One       Date:  2010-09-30       Impact factor: 3.240
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