Literature DB >> 1525708

The effect of a new vitamin D analog, 22-oxa-1 alpha,25(OH)2D3, on bone mineral metabolism in normal male rats.

M Takizawa1, M Fallon, B Stein, S Epstein.   

Abstract

The in vivo effects of 22-oxa-1 alpha,25 dihydroxyvitamin D3 (OCT), on bone mineral metabolism were investigated in normal male Sprague-Dawley rats. The rats were administered either vehicle (control), low-dose OCT (25 ng/100 g body weight), or high-dose OCT (250 ng/100 g body wt). High-dose OCT increased serum ionized calcium (P less than 0.05) and decreased serum parathyroid hormone (PTH) (P less than 0.05) at all time points and increased serum bone Gla protein on days 7 and 28 (P less than 0.05) compared with controls. Low-dose OCT decreased serum PTH at all the time points (P less than 0.05) compared with controls. Tibial bone histomorphometry showed no significant differences between the two doses of OCT and controls. We found that OCT has minimal direct effects on bone metabolism in normal male rats in contrast to 1,25 dihydroxyvitamin D3. This property may be advantageous in the treatment with OCT of cell-proliferative diseases.

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Year:  1992        PMID： 1525708     DOI： 10.1007/bf00582166

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  13 in total

Review 1.  The vitamin D-induced differentiation of HL-60 cells: structural requirements.

Authors:  V K Ostrem; H F DeLuca
Journal:  Steroids       Date:  1987 Jan-Mar       Impact factor: 2.668

2.  Synthetic analogues of vitamin D3 with an oxygen atom in the side chain skeleton. A trial of the development of vitamin D compounds which exhibit potent differentiation-inducing activity without inducing hypercalcemia.

Authors:  J Abe; M Morikawa; K Miyamoto; S Kaiho; M Fukushima; C Miyaura; E Abe; T Suda; Y Nishii
Journal:  FEBS Lett       Date:  1987-12-21       Impact factor: 4.124

3.  1,25 Dihydroxyvitamin D3 modifies cyclosporine-induced bone loss.

Authors:  S Epstein; M Schlosberg; M Fallon; S Thomas; C Movsowitz; F Ismail
Journal:  Calcif Tissue Int       Date:  1990-09       Impact factor: 4.333

Review 4.  The D vitamins and bone.

Authors:  P H Stern
Journal:  Pharmacol Rev       Date:  1980-03       Impact factor: 25.468

5.  A synthetic analogue of vitamin D3, 22-oxa-1 alpha,25-dihydroxyvitamin D3, is a potent modulator of in vivo immunoregulating activity without inducing hypercalcemia in mice.

Authors:  J Abe; Y Takita; T Nakano; C Miyaura; T Suda; Y Nishii
Journal:  Endocrinology       Date:  1989-05       Impact factor: 4.736

6.  Affinity of 22-oxa-1,25(OH)2D3 for 1,25-dihydroxyvitamin D receptor and its effects on the synthesis of osteocalcin in human osteosarcoma cells.

Authors:  T Valaja; A Mahonen; A Pirskanen; P H Mäenpää
Journal:  Biochem Biophys Res Commun       Date:  1990-06-15       Impact factor: 3.575

7.  1 alpha,25-Dihydroxyvitamin D3 and 1 alpha-hydroxyvitamin D3 prolong survival time of mice inoculated with myeloid leukemia cells.

Authors:  Y Honma; M Hozumi; E Abe; K Konno; M Fukushima; S Hata; Y Nishii; H F DeLuca; T Suda
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

8.  Regulation of terminal differentiation of cultured mouse epidermal cells by 1 alpha,25-dihydroxyvitamin D3.

Authors:  J Hosomi; J Hosoi; E Abe; T Suda; T Kuroki
Journal:  Endocrinology       Date:  1983-12       Impact factor: 4.736

9.  The noncalcemic analogue of vitamin D, 22-oxacalcitriol, suppresses parathyroid hormone synthesis and secretion.

Authors:  A J Brown; C R Ritter; J L Finch; J Morrissey; K J Martin; E Murayama; Y Nishii; E Slatopolsky
Journal:  J Clin Invest       Date:  1989-09       Impact factor: 14.808

10.  Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.

Authors:  E Abe; C Miyaura; H Sakagami; M Takeda; K Konno; T Yamazaki; S Yoshiki; T Suda
Journal:  Proc Natl Acad Sci U S A       Date:  1981-08       Impact factor: 11.205
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  2 in total

1.  A novel synthetic vitamin D analogue, 2 beta-(3-hydroxypropoxy)1 alpha, 25-dihydroxyvitamin D3 (ED-71), increases bone mass by stimulating the bone formation in normal and ovariectomized rats.

Authors:  H Tsurukami; T Nakamura; K Suzuki; K Sato; Y Higuchi; Y Nishii
Journal:  Calcif Tissue Int       Date:  1994-02       Impact factor: 4.333

2.  Parathyroid hormone suppression by 22-oxacalcitriol in the severe parathyroid hyperplasia.

Authors:  H Funahashi; Y Tanaka; T Imai; M Wada; K Tsukamura; Y Hayakawa; N Matsuura; T Kikumori; M Oiwa; Y Tominaga; H Takagi
Journal:  J Endocrinol Invest       Date:  1998-01       Impact factor: 4.256
  2 in total

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