Literature DB >> 15256411

Extracting gene pathway relations using a hybrid grammar: the Arizona Relation Parser.

Daniel M McDonald1, Hsinchun Chen, Hua Su, Byron B Marshall.   

Abstract

MOTIVATION: Text-mining research in the biomedical domain has been motivated by the rapid growth of new research findings. Improving the accessibility of findings has potential to speed hypothesis generation.
RESULTS: We present the Arizona Relation Parser that differs from other parsers in its use of a broad coverage syntax-semantic hybrid grammar. While syntax grammars have generally been tested over more documents, semantic grammars have outperformed them in precision and recall. We combined access to syntax and semantic information from a single grammar. The parser was trained using 40 PubMed abstracts and then tested using 100 unseen abstracts, half for precision and half for recall. Expert evaluation showed that the parser extracted biologically relevant relations with 89% precision. Recall of expert identified relations with semantic filtering was 35 and 61% before semantic filtering. Such results approach the higher-performing semantic parsers. However, the AZ parser was tested over a greater variety of writing styles and semantic content. AVAILABILITY: Relations extracted from over 600 000 PubMed abstracts are available for retrieval and visualization at http://econport.arizona.edu:8080/NetVis/index.html.

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Year:  2004        PMID: 15256411     DOI: 10.1093/bioinformatics/bth409

Source DB:  PubMed          Journal:  Bioinformatics        ISSN: 1367-4803            Impact factor:   6.937


  3 in total

1.  Global mapping of gene/protein interactions in PubMed abstracts: a framework and an experiment with P53 interactions.

Authors:  Xin Li; Hsinchun Chen; Zan Huang; Hua Su; Jesse D Martinez
Journal:  J Biomed Inform       Date:  2007-01-17       Impact factor: 6.317

2.  Connecting the dots between PubMed abstracts.

Authors:  M Shahriar Hossain; Joseph Gresock; Yvette Edmonds; Richard Helm; Malcolm Potts; Naren Ramakrishnan
Journal:  PLoS One       Date:  2012-01-03       Impact factor: 3.240

3.  New challenges for text mining: mapping between text and manually curated pathways.

Authors:  Kanae Oda; Jin-Dong Kim; Tomoko Ohta; Daisuke Okanohara; Takuya Matsuzaki; Yuka Tateisi; Jun'ichi Tsujii
Journal:  BMC Bioinformatics       Date:  2008-04-11       Impact factor: 3.169

  3 in total

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