Literature DB >> 15255191

The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A.

Hajime Hiramatsu1, Atsushi Yamamoto, Kiyoshi Kyono, Yutaka Higashiyama, Chiaki Fukushima, Hideaki Shima, Shigeru Sugiyama, Koji Inaka, Ryo Shimizu.   

Abstract

Dipeptidyl peptidase IV (DPPIV) is a serine protease, a member of the prolyl oligopeptidase (POP) family, and has been implicated in several diseases. Therefore, it seems important to develop selective inhibitors for human DPPIV (hDPPIV) that are able to control the biological function of hDPPIV. In order to elucidate the binding mode and substrate specificity, we determined the crystal structure complex of hDPPIV and diprotin A (IIe-Pro-IIe), a slowly hydrolyzed substrate of hDPPIV, at 2.2 A resolution. In this paper, we discuss the molecular interaction mechanism of diprotin A with hDPPIV based on the X-ray crystal structure.

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Year:  2004        PMID： 15255191     DOI： 10.1515/BC.2004.068

Source DB:  PubMed          Journal:  Biol Chem        ISSN： 1431-6730            Impact factor:   3.915


  10 in total

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  10 in total

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