Literature DB >> 15254940

A consanguineous Turkish family with early-onset Parkinson's disease and an exon 4 parkin deletion.

Okan Dogu1,2, Janel Johnson2, Dena Hernandez2, Melissa Hanson2, John Hardy2, Hulya Apaydin3, Sibel Özekmekçi3, Serhan Sevim1, Katrina Gwinn-Hardy2, Andrew Singleton2.   

Abstract

The importance of parkin in early-onset Parkinson's disease in Japan, Europe, and the United States is well established. The contribution of this gene to the risk of Parkinson's disease in other populations is less well known. To explore the importance of parkin in those of Turkish ancestry, we studied familial cases from that country, and identified a consanguineous family with early-onset Parkinson's disease due to a homozygous mutation in parkin. Copyright 2004 Movement Disorder Society

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Year:  2004        PMID： 15254940     DOI： 10.1002/mds.20028

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


  5 in total

Review 1.  Twenty years since the discovery of the parkin gene.

Authors:  Nobutaka Hattori; Yoshikuni Mizuno
Journal:  J Neural Transm (Vienna)       Date:  2017-06-15       Impact factor: 3.575

2.  Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activation.

Authors:  Yong Ren; Houbo Jiang; Fang Yang; Kazuhiro Nakaso; Jian Feng
Journal:  J Biol Chem       Date:  2008-12-11       Impact factor: 5.157

3.  Smoking-induced transient motor deterioration in a levodopa-treated patient with Parkinson's disease.

Authors:  Helen Ling; Igor Petrovic; Brian L Day; Andrew J Lees
Journal:  J Neurol       Date:  2012-05-10       Impact factor: 4.849

4.  Early-onset L-dopa-responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutations.

Authors:  Coro Paisán-Ruiz; Rocio Guevara; Monica Federoff; Hasmet Hanagasi; Fardaz Sina; Elahe Elahi; Susanne A Schneider; Petra Schwingenschuh; Nin Bajaj; Murat Emre; Andrew B Singleton; John Hardy; Kailash P Bhatia; Sebastian Brandner; Andrew J Lees; Henry Houlden
Journal:  Mov Disord       Date:  2010-09-15       Impact factor: 10.338

5.  PARKIN, PINK1, and DJ1 analysis in early-onset Parkinson's disease in Ireland.

Authors:  Diana A Olszewska; Allan McCarthy; Owen A Ross; Tim Lynch; Alexandra I Soto-Beasley; Ronald L Walton
Journal:  Ir J Med Sci       Date:  2021-03-22       Impact factor: 2.089
  5 in total

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