Pax6 is a direct, positively regulated target of the circadian gene Clock.

Clock is a member of a highly conserved transcription control network that underlies the circadian cycle. During early embryogenesis, its expression is developmentally regulated and may be required for the normal development of the head. In this report, the transcription factor Pax6, a highly conserved regulator of anterior development, is shown to be a direct target of Clock regulation. Copyright 2004 Wiley-Liss, Inc.