Literature DB >> 15254774

Induction of apoptosis by ar-turmerone on various cell lines.

Mingjie Ji1, Jaesue Choi, Jeongnyeo Lee, Yongkyu Lee.   

Abstract

This study investigated the cytotoxic effect of ar-turmerone isolated from turmeric (Curcuma longa L) on the K562, L1210, U937 and RBL-2H3 cell lines by the MTT assay. Ar-turmerone exhibited potent cytotoxicity on these cancer cell lines. The IC50 values of ar-turmerone on these cell lines were 20-50 microg/ml. They showed an increased inhibition ratio on cell viability according to the drug concentration < or = 80 microg/ml in the cell lines tested. The DNA fragmentation that is a characteristic of apoptosis due to ar-turmerone occurred in a concentration- and time-dependent manner in the K562, L1210, U937 and RBL-2H3 cancer cell lines. These results suggest that ar-turmerone can induce the apoptotic activity in the K562, L1210, U937 and RBL-2H3 cells.

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Year:  2004        PMID： 15254774

Source DB:  PubMed          Journal:  Int J Mol Med        ISSN： 1107-3756            Impact factor:   4.101


  17 in total

1.  The role of turmerones on curcumin transportation and P-glycoprotein activities in intestinal Caco-2 cells.

Authors:  Grace G L Yue; Sau-Wan Cheng; Hua Yu; Zi-Sheng Xu; Julia K M Lee; Po-Ming Hon; Mavis Y H Lee; Edward J Kennelly; Gary Deng; Simon K Yeung; Barrie R Cassileth; Kwok-Pui Fung; Ping-Chung Leung; Clara B S Lau
Journal:  J Med Food       Date:  2011-12-19       Impact factor: 2.786

Review 2.  Interaction of turmeric (Curcuma longa L.) with beneficial microbes: a review.

Authors:  Ajay Kumar; Amit Kishore Singh; Manish Singh Kaushik; Surabhi Kirti Mishra; Pratima Raj; P K Singh; K D Pandey
Journal:  3 Biotech       Date:  2017-10-03       Impact factor: 2.406

3.  Anti-arthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.).

Authors:  Janet L Funk; Jennifer B Frye; Janice N Oyarzo; Huaping Zhang; Barbara N Timmermann
Journal:  J Agric Food Chem       Date:  2010-01-27       Impact factor: 5.279

4.  Inhaled turmerones can be incorporated in the organs via pathways different from oral administration and can affect weight-gain of mice.

Authors:  Yuki Takemoto; Chihiro Kishi; Hinano Ehira; Nobutaka Matsui; Taichi Yamaguchi; Yuri Yoshioka; Shinichi Matsumura; Tatsuya Moriyama; Nobuhiro Zaima
Journal:  Sci Rep       Date:  2022-06-30       Impact factor: 4.996

5.  Maturation and upregulation of functions of murine dendritic cells (DCs) under the influence of purified aromatic-turmerone (AR).

Authors:  Tan Yonggang; Meng Yiming; Zhang Heying; Sun Cheng; Wang Qiushi; Yang Xianghong; Zheng Wei; Zhou Huawei; Fengping Shan
Journal:  Hum Vaccin Immunother       Date:  2012-10-01       Impact factor: 3.452

6.  Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa.

Authors:  Grace G L Yue; Ben C L Chan; Po-Ming Hon; Mavis Y H Lee; Kwok-Pui Fung; Ping-Chung Leung; Clara B S Lau
Journal:  Food Chem Toxicol       Date:  2010-05-09       Impact factor: 6.023

7.  Ginger and turmeric expressed sequence tags identify signature genes for rhizome identity and development and the biosynthesis of curcuminoids, gingerols and terpenoids.

Authors:  Hyun Jo Koo; Eric T McDowell; Xiaoqiang Ma; Kevin A Greer; Jeremy Kapteyn; Zhengzhi Xie; Anne Descour; HyeRan Kim; Yeisoo Yu; David Kudrna; Rod A Wing; Carol A Soderlund; David R Gang
Journal:  BMC Plant Biol       Date:  2013-02-15       Impact factor: 4.215

8.  Aromatic-Turmerone Analogs Protect Dopaminergic Neurons in Midbrain Slice Cultures through Their Neuroprotective Activities.

Authors:  Yuria Hori; Reiho Tsutsumi; Kento Nasu; Alex Boateng; Yasuhiko Ashikari; Masaharu Sugiura; Makoto Nakajima; Yuki Kurauchi; Akinori Hisatsune; Hiroshi Katsuki; Takahiro Seki
Journal:  Cells       Date:  2021-05-03       Impact factor: 6.600

9.  Correlation between Chemical Composition of Curcuma domestica and Curcuma xanthorrhiza and Their Antioxidant Effect on Human Low-Density Lipoprotein Oxidation.

Authors:  Ibrahim Jantan; Fadlina Chany Saputri; Muhammad Naeem Qaisar; Fhataheya Buang
Journal:  Evid Based Complement Alternat Med       Date:  2012-11-26       Impact factor: 2.629

10.  Hepatic protection and anticancer activity of curcuma: a potential chemopreventive strategy against hepatocellular carcinoma.

Authors:  Yan Li; Xue Shi; Jingwen Zhang; Xiang Zhang; Robert C G Martin
Journal:  Int J Oncol       Date:  2013-11-21       Impact factor: 5.650
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