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Literature DB >> 15254415

Dynamics in the p53-Mdm2 ubiquitination pathway.

Abstract

The tumor suppressor p53 is highly regulated under various states of cellular stress. p53 stability is predominantly regulated through the ubiquitin-proteasomal pathway by the E3 ligase Mdm2. p53 ubiquitination is a dynamic process with Mdm2 capable of catalyzing both mono- and polyubiquitination. Additionally, deubiquitination is an important step occurring in p53 and Mdm2 stabilities. Factors such as HAUSP, p14(ARF), and MdmX play important regulatory roles in p53 ubiquitination/deubiquitination and their interplay with Mdm2 and p53 compound layers of complexity for regulating this important pathway.

Entities: Disease Gene

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Year: 2004 PMID： 15254415

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

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Cited

33 in total

Dynamics in the p53-Mdm2 ubiquitination pathway.

1. Transcriptional regulation of HIV-1 gene expression by p53.

2. Inhibition of TFII-I-dependent cell cycle regulation by p53.

3. JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress.

4. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.

5. A function for the RING finger domain in the allosteric control of MDM2 conformation and activity.

6. Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays.

Review 7. The enzymes in ubiquitin-like post-translational modifications.

8. Harmonic oscillations in homeostatic controllers: Dynamics of the p53 regulatory system.

9. Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis.

10. 9-Aminoacridine inhibition of HIV-1 Tat dependent transcription.