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Literature DB >> 15254399

The finger domain of the human deubiquitinating enzyme HAUSP is a zinc ribbon.

Abstract

Human deubiquitinating enzyme HAUSP is a cysteine protease that regulates the levels of the tumor suppressor protein p53. By comparative sequence and structural analysis, we show that the previously uncharacterized finger domain insert to the catalytic core of HAUSP is a zinc ribbon that has lost its zinc-binding ability.

Entities: Disease Gene Species

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Year: 2004 PMID： 15254399

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

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Cited

9 in total

1. Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain-like protease?

Authors: Traian Sulea; Holger A Lindner; Enrico O Purisima; Robert Ménard
Journal: J Virol Date: 2005-04 Impact factor: 5.103

2. Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.

Authors: Min Hu; Pingwei Li; Ling Song; Philip D Jeffrey; Tatiana A Chenova; Keith D Wilkinson; Robert E Cohen; Yigong Shi
Journal: EMBO J Date: 2005-10-06 Impact factor: 11.598

3. The bridge-region of the Ku superfamily is an atypical zinc ribbon domain.

Authors: S Sri Krishna; L Aravind
Journal: J Struct Biol Date: 2010-05-23 Impact factor: 2.867

4. Divergence in Ubiquitin Interaction and Catalysis among the Ubiquitin-Specific Protease Family Deubiquitinating Enzymes.

Authors: Adam H Tencer; Qin Liang; Zhihao Zhuang
Journal: Biochemistry Date: 2016-08-08 Impact factor: 3.162

The finger domain of the human deubiquitinating enzyme HAUSP is a zinc ribbon.

1. Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain-like protease?

2. Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.

3. The bridge-region of the Ku superfamily is an atypical zinc ribbon domain.

4. Divergence in Ubiquitin Interaction and Catalysis among the Ubiquitin-Specific Protease Family Deubiquitinating Enzymes.

Review 5. The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases.

6. Binding site-based classification of coronaviral papain-like proteases.

7. Structural basis of ubiquitin recognition by the deubiquitinating protease USP2.

8. The SHOCT domain: a widespread domain under-represented in model organisms.

9. High incidence of ubiquitin-like domains in human ubiquitin-specific proteases.