Literature DB >> 15254396

The ARTS connection: role of ARTS in apoptosis and cancer.

Sarit Larisch1.   

Abstract

ARTS is an unusual septin that is localized to mitochondria in living cells and promotes apoptosis by antagonizing IAPs. ARTS functions as a tumor suppressor in Acute Lymphoblastic Leukemia (ALL) and is lost in more than 70% of leukemic patients. The loss of ARTS is specific as levels of H5, a closely related non-apoptotic septin protein derived from the same gene, were unaffected. Thus, ARTS, a new member in the mitochondrial pro-apoptotic arsenal, provides a link between mitochondria, apoptosis and cancer.

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Year:  2004        PMID： 15254396

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  10 in total

1.  SEPT4 is regulated by the Notch signaling pathway.

Authors:  Wenbin Liu
Journal:  Mol Biol Rep       Date:  2011-09-22       Impact factor: 2.316

Review 2.  Conquering the complex world of human septins: implications for health and disease.

Authors:  E A Peterson; E M Petty
Journal:  Clin Genet       Date:  2010-02-11       Impact factor: 4.438

Review 3.  Some assembly required: yeast septins provide the instruction manual.

Authors:  Matthias Versele; Jeremy Thorner
Journal:  Trends Cell Biol       Date:  2005-08       Impact factor: 20.808

4.  Septins stabilize mitochondria in Tetrahymena thermophila.

Authors:  D Wloga; I Strzyzewska-Jówko; J Gaertig; M Jerka-Dziadosz
Journal:  Eukaryot Cell       Date:  2008-06-27

5.  Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin.

Authors:  Esther A Peterson; Linda M Kalikin; Jonathan D Steels; Mathew P Estey; William S Trimble; Elizabeth M Petty
Journal:  Mamm Genome       Date:  2007-10-06       Impact factor: 2.957

6.  Forchlorfenuron alters mammalian septin assembly, organization, and dynamics.

Authors:  Qicong Hu; W James Nelson; Elias T Spiliotis
Journal:  J Biol Chem       Date:  2008-08-18       Impact factor: 5.157

Review 7.  [Functional Characterization of Septin Complexes].

Authors:  K A Akhmetova; I N Chesnokov; S A Fedorova
Journal:  Mol Biol (Mosk)       Date:  2018 Mar-Apr

8.  Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation.

Authors:  Naijin Zhang; Ying Zhang; Shilong You; Yichen Tian; Saien Lu; Liu Cao; Yingxian Sun
Journal:  Int J Biol Sci       Date:  2020-01-14       Impact factor: 6.580

9.  Septin4 promotes cell death in human colon cancer cells by interacting with BAX.

Authors:  Xin Zhao; Hao Feng; Yang Wang; Yanmei Wu; Qiqiang Guo; Yanling Feng; Mengtao Ma; Wendong Guo; Xiaoyu Song; Ying Zhang; Shuai Han; Liu Cao
Journal:  Int J Biol Sci       Date:  2020-04-07       Impact factor: 6.580

10.  ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.

Authors:  Elle Koren; Yahav Yosefzon; Roi Ankawa; Despina Soteriou; Avi Jacob; Alexander Nevelsky; Rahamim Ben-Yosef; Gil Bar-Sela; Yaron Fuchs
Journal:  Nat Commun       Date:  2018-11-02       Impact factor: 14.919
  10 in total

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