Literature DB >> 15253691

Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes.

Katrina A Bicknell1, Carmen H Coxon, Gavin Brooks.   

Abstract

Repair of the mature mammalian myocardium following injury is impaired by the inability of the majority of cardiomyocytes to undergo cell division. We show that overexpression of the cyclin B1-CDC2 (cell division cycle 2 kinase) complex re-initiates cell division in adult cardiomyocytes. Thus strategies targeting the cyclin B1-CDC2 complex might re-initiate cell division in mature cardiomyocytes in vivo and facilitate myocardial regeneration following injury.

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Year:  2004        PMID： 15253691      PMCID： PMC1133796          DOI： 10.1042/BJ20031481

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  25 in total

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Authors:  G Brooks; R A Poolman; C J McGill; J M Li
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9.  Positivity of the proliferation marker Ki-67 in noncycling cells.

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  26 in total

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7.  Harnessing the Induction of Cardiomyocyte Proliferation for Cardiac Regenerative Medicine.

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9.  FGF-16 is released from neonatal cardiac myocytes and alters growth-related signaling: a possible role in postnatal development.

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10.  Over expression of Plk1 does not induce cell division in rat cardiac myocytes in vitro.

Authors:  Carmen H Coxon; Katrina A Bicknell; Fleur L Moseley; Gavin Brooks
Journal:  PLoS One       Date:  2009-08-25       Impact factor: 3.240
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