Literature DB >> 15252488

Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridoquinoxaline)copper(II) complex.

Shanta Dhar1, Pattubala A N Reddy, Akhil R Chakravarty.   

Abstract

The axial aqua bound copper(II) complex [Cu(dpq)2(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 +/- 0.4 h(-1) and a rate enhancement of 1.55 x 10(8).

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Year:  2004        PMID： 15252488     DOI： 10.1039/b401383b

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  5 in total

1.  Efficient hydrolytic cleavage of DNA and antiproliferative effect on human cancer cells by two dinuclear Cu(II) complexes containing a carbohydrazone ligand and 1,10-phenanthroline as a coligand.

Authors:  Sidhali U Parsekar; Manohar Singh; Durga P Mishra; P K Sudhadevi Antharjanam; Aditya P Koley; Manjuri Kumar
Journal:  J Biol Inorg Chem       Date:  2019-03-18       Impact factor: 3.358

2.  Mixed Ligand Mononuclear Copper(II) Complex as a Promising Anticancer Agent: Interaction Studies with DNA/HSA, Molecular Docking, and In Vitro Cytotoxicity Studies.

Authors:  Kumudini Paliwal; Paramita Haldar; P K Sudhadevi Antharjanam; Manjuri Kumar
Journal:  ACS Omega       Date:  2022-06-13

3.  DNA oxidative cleavage induced by the novel peptide derivatives of 3-(quinoxalin-6-yl)alanine in combination with Cu(II) or Fe(II) ions.

Authors:  Wojciech Szczepanik; Marzena Kucharczyk-Klamińska; Piotr Stefanowicz; Anna Staszewska; Zbigniew Szewczuk; Jacek Skała; Andrzej Mysiak; Małgorzata Jezowska-Bojczuk
Journal:  Bioinorg Chem Appl       Date:  2010-03-08       Impact factor: 7.778

4.  DNA binding, cleavage and cytotoxicity studies of three mononuclear Cu(II) chloro-complexes containing N-S donor Schiff base ligands.

Authors:  Sidhali U Parsekar; Joseph Fernandes; Arnab Banerjee; Om Prakash Chouhan; Sumit Biswas; Manohar Singh; Durga P Mishra; Manjuri Kumar
Journal:  J Biol Inorg Chem       Date:  2018-10-09       Impact factor: 3.358

5.  Synthesis, Characterization, Crystal Structure, DNA and HSA Interactions, and Anticancer Activity of a Mononuclear Cu(II) Complex with a Schiff Base Ligand Containing a Thiadiazoline Moiety.

Authors:  Sidhali U Parsekar; Kumudini Paliwal; Paramita Haldar; P K Sudhadevi Antharjanam; Manjuri Kumar
Journal:  ACS Omega       Date:  2022-01-10
  5 in total

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