P R Blackett MD1, D A Freeman MD. 1. Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA.
Abstract
OBJECTIVE: To report two cases of gynecomastia that occurred in boys with 11beta-hydroxylase and 21-hydroxylase deficiency. METHODS: We describe the physical findings and summarize the laboratory evaluation and treatment of two cases encountered in our medical practice. RESULTS: Both of our patients (a 4-year-old boy and a 17-year-old boy) had extreme virilization and gynecomastia; on laboratory assessment, androstenedione and estrogen levels were high. Treatment with hydrocortisone was recommended. CONCLUSION: Peripheral conversion of adrenal androgen to estrogen likely caused the feminizing syndrome in these patients.
OBJECTIVE: To report two cases of gynecomastia that occurred in boys with 11beta-hydroxylase and 21-hydroxylase deficiency. METHODS: We describe the physical findings and summarize the laboratory evaluation and treatment of two cases encountered in our medical practice. RESULTS: Both of our patients (a 4-year-old boy and a 17-year-old boy) had extreme virilization and gynecomastia; on laboratory assessment, androstenedione and estrogen levels were high. Treatment with hydrocortisone was recommended. CONCLUSION: Peripheral conversion of adrenal androgen to estrogen likely caused the feminizing syndrome in these patients.