| Literature DB >> 15251463 |
Kota V Ramana1, Aruni Bhatnagar, Satish K Srivastava.
Abstract
In this study, we examined the role of aldose reductase (AR) in regulating the cytotoxic effects of TNF-alpha on human umbilical vein endothelial cells. Inhibition of AR by sorbinil or tolrestat prevented TNF-alpha-induced increase in Bax and Bak and the downregulation of Bcl-2. Inhibition of AR abrogated AP-1 DNA binding activity and prevented the activation of caspase-3, JNK, and p38 MAPK in cells stimulated by TNF-alpha. Exposure to TNF-alpha also induced apoptotic cell death, which was attenuated by AR inhibition or antisense ablation. These observations suggest that AR is a critical regulator of TNF-alpha-induced apoptotic signaling in endothelial cells.Entities:
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Year: 2004 PMID： 15251463 DOI： 10.1016/j.febslet.2004.06.046
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124