Literature DB >> 15251154

Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression.

Alberto Mantovani1, Paola Allavena, Antonio Sica.   

Abstract

Macrophages are versatile, plastic cells which respond to micro-environmental signals with distinct functional programmes. In the tumour microenvironment, tumour-associated macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion of tissue remodelling and repair. As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote tumour progression.

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Year:  2004        PMID： 15251154     DOI： 10.1016/j.ejca.2004.03.016

Source DB:  PubMed          Journal:  Eur J Cancer        ISSN： 0959-8049            Impact factor:   9.162


  102 in total

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