OBJECTIVE: To define the relation between the size of a CIN 3 lesion (measured histologically) and invasive squamous carcinoma. DESIGN: Measurement of CIN 3 by computerized planimetry of histological sections from 39 cone biopsies containing microinvasive cancer. Comparison with previous measurements of CIN lesions, associated with different grades of dyskaryosis. RESULTS: Microinvasive carcinoma of the cervix is associated with extensive CIN 3 on the surface and in endocervical crypts. The mean size of CIN 3 lesions showing microinvasion is seven times greater than that for severe dyskaryosis without invasion, (P less than 0.0001) and a 100-fold greater than with mild dyskaryosis (P less than 0.00001). CONCLUSION: Invasive squamous carcinoma of the cervix arises in large CIN 3 lesions and these are associated usually with severe dyskaryosis. We propose a model for the development of high-grade precancer as a small focus within low grade precancer which then undergoes expansion in size, accompanied by apparent progression in cytological grade.
OBJECTIVE: To define the relation between the size of a CIN 3 lesion (measured histologically) and invasive squamous carcinoma. DESIGN: Measurement of CIN 3 by computerized planimetry of histological sections from 39 cone biopsies containing microinvasive cancer. Comparison with previous measurements of CIN lesions, associated with different grades of dyskaryosis. RESULTS:Microinvasive carcinoma of the cervix is associated with extensive CIN 3 on the surface and in endocervical crypts. The mean size of CIN 3 lesions showing microinvasion is seven times greater than that for severe dyskaryosis without invasion, (P less than 0.0001) and a 100-fold greater than with mild dyskaryosis (P less than 0.00001). CONCLUSION:Invasive squamous carcinoma of the cervix arises in large CIN 3 lesions and these are associated usually with severe dyskaryosis. We propose a model for the development of high-grade precancer as a small focus within low grade precancer which then undergoes expansion in size, accompanied by apparent progression in cytological grade.
Authors: Hannah P Yang; Rosemary E Zuna; Mark Schiffman; Joan L Walker; Mark E Sherman; Lisa M Landrum; Katherine Moxley; Michael A Gold; S Terence Dunn; Richard A Allen; Roy Zhang; Rodney Long; Sophia S Wang; Nicolas Wentzensen Journal: PLoS One Date: 2012-01-13 Impact factor: 3.240
Authors: Mario Sideri; Paola Garutti; Silvano Costa; Paolo Cristiani; Patrizia Schincaglia; Priscilla Sassoli de Bianchi; Carlo Naldoni; Lauro Bucchi Journal: Biomed Res Int Date: 2015-06-09 Impact factor: 3.411