Registration-based interpolation.

A method is presented to interpolate between neighboring slices in a grey-scale tomographic data set. Spatial correspondence between adjacent slices is established using a nonrigid registration algorithm based on B-splines which optimizes the normalized mutual information similarity measure. Linear interpolation of the image intensities is then carried out along the directions calculated by the registration algorithm. The registration-based method is compared to both standard linear interpolation and shape-based interpolation in 20 tomographic data sets. Results show that the proposed method statistically significantly outperforms both linear and shape-based interpolation.