OBJECTIVE: To study the therapeutic mechanism of weitongning (WTN) in treating peptic ulcer. METHODS: Rat model of chronic gastric ulcer induced by glacial acetic acid was used to observe the effect of WTN on the curative quality, thickness of regenerated mucous membrane, epidermal growth factor (EGF) and nitric oxide (NO) contents in scar tissue around the gastric ulcer. RESULTS: The thickness of regenerated mucous membrane, EGF and NO contents in peri-ulcer scar tissue were higher in the model rats after WTN treatment than that in the untreated model rats (P<0.01 or P<0.05). CONCLUSION: WTN could elevate the quality of ulcer curing, to raise the EGF and NO contents in peri-ulcer scar tissue might be one of its mechanisms for preventing relapse of peptic ulcer.
OBJECTIVE: To study the therapeutic mechanism of weitongning (WTN) in treating peptic ulcer. METHODS:Rat model of chronic gastric ulcer induced by glacial acetic acid was used to observe the effect of WTN on the curative quality, thickness of regenerated mucous membrane, epidermal growth factor (EGF) and nitric oxide (NO) contents in scar tissue around the gastric ulcer. RESULTS: The thickness of regenerated mucous membrane, EGF and NO contents in peri-ulcer scar tissue were higher in the model rats after WTN treatment than that in the untreated model rats (P<0.01 or P<0.05). CONCLUSION: WTN could elevate the quality of ulcer curing, to raise the EGF and NO contents in peri-ulcer scar tissue might be one of its mechanisms for preventing relapse of peptic ulcer.