Literature DB >> 15249634

Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population.

S Helisalmi1, B Dermaut, M Hiltunen, A Mannermaa, M Van den Broeck, M Lehtovirta, A M Koivisto, S Iivonen, M Cruts, H Soininen, C Van Broeckhoven.   

Abstract

The authors previously reported that genetic variation in the gene coding for nicastrin (NCSTN) modified risk for familial early-onset Alzheimer disease (AD) in a Dutch population-based sample. Risk was highest in patients without an APOE epsilon4 allele. Here, they evaluated if NCSTN polymorphisms increased risk of AD in the eastern Finnish population. A significant difference in one haplotype was observed in AD patients without the APOE epsilon4 allele.

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Year:  2004        PMID： 15249634     DOI： 10.1212/01.wnl.0000133153.98139.4e

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  5 in total

1.  Evidence for three loci modifying age-at-onset of Alzheimer's disease in early-onset PSEN2 families.

Authors:  Elizabeth E Marchani; Thomas D Bird; Ellen J Steinbart; Elisabeth Rosenthal; Chang-En Yu; Gerard D Schellenberg; Ellen M Wijsman
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2010-07       Impact factor: 3.568

2.  Variants regulating ZBTB4 are associated with age-at-onset of Alzheimer's disease.

Authors:  E E Blue; C-E Yu; T A Thornton; N H Chapman; E Kernfeld; N Jiang; K M Shively; K J Buckingham; C T Marvin; M J Bamshad; T D Bird; E M Wijsman
Journal:  Genes Brain Behav       Date:  2017-11-20       Impact factor: 3.449

3.  Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease.

Authors:  Michelle K Lupton; Petroula Proitsi; Makrina Danillidou; Magda Tsolaki; Gillian Hamilton; Richard Wroe; Megan Pritchard; Kathryn Lord; Belinda M Martin; Iwona Kloszewska; Hilkka Soininen; Patrizia Mecocci; Bruno Vellas; Denise Harold; Paul Hollingworth; Simon Lovestone; John F Powell
Journal:  PLoS One       Date:  2011-02-25       Impact factor: 3.240

4.  Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.

Authors:  Gillian Hamilton; Richard Killick; Jean-Charles Lambert; Philippe Amouyel; Minerva M Carrasquillo; V Shane Pankratz; Neill R Graff-Radford; Dennis W Dickson; Ronald C Petersen; Steven G Younkin; John F Powell; Richard Wade-Martins
Journal:  Neurobiol Aging       Date:  2012-03-08       Impact factor: 4.673

5.  Neuron-specific deletion of presenilin enhancer2 causes progressive astrogliosis and age-related neurodegeneration in the cortex independent of the Notch signaling.

Authors:  Hui-Ru Bi; Cui-Hua Zhou; Yi-Zhi Zhang; Xu-Dong Cai; Mu-Huo Ji; Jian-Jun Yang; Gui-Quan Chen; Yi-Min Hu
Journal:  CNS Neurosci Ther       Date:  2020-09-22       Impact factor: 5.243
  5 in total

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