Henry A Nasrallah1, Thantween White, Amelia T Nasrallah. 1. Department of Psychiatry, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, OH 45267-0559, USA. henry.nasrallah@uc.edu
Abstract
OBJECTIVE: The authors examined the mortality rate in geriatric patients receiving either haloperidol or atypical antipsychotics. METHODS: Authors tracked mortality over a 2-year period in patients age 65 years or older receiving haloperidol (N=299) or the atypical antipsychotics risperidone or olanzapine (N= 1,254). RESULTS: Sixty-four patients in the haloperidol group (21.4%) and 61 patients in the atypical group (4.75%) died during the 2-year study period. The difference was statistically significant. CONCLUSIONS: The findings suggest that mortality in elderly patients receiving haloperidol is significantly higher than in those receiving the atypical antipsychotics risperidone or olanzapine. Authors discuss possible causal mechanisms.
OBJECTIVE: The authors examined the mortality rate in geriatric patients receiving either haloperidol or atypical antipsychotics. METHODS: Authors tracked mortality over a 2-year period in patients age 65 years or older receiving haloperidol (N=299) or the atypical antipsychotics risperidone or olanzapine (N= 1,254). RESULTS: Sixty-four patients in the haloperidol group (21.4%) and 61 patients in the atypical group (4.75%) died during the 2-year study period. The difference was statistically significant. CONCLUSIONS: The findings suggest that mortality in elderly patients receiving haloperidol is significantly higher than in those receiving the atypical antipsychotics risperidone or olanzapine. Authors discuss possible causal mechanisms.
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