Literature DB >> 1524723

alpha-Methyl tryptophan as a tracer for in vivo studies of brain serotonin system, from autoradiography to positron emission tomography.

M Diksic1.   

Abstract

The procedure for measuring the brain serotonin synthesis rate in living brain using labelled alpha-methyl-L-tryptophan (alpha-MTrp), a tryptophan analog, is described. This tracer could also be used for the anterograde axonal transport measurement of serotonin. One advantage of this method is that alpha-MTrp is converted in situ into a serotonin tracer, alpha-methyl serotonin, and should be distributed into the same compartments as serotonin.

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Year:  1992        PMID： 1524723     DOI： 10.1016/0891-0618(92)90026-m

Source DB:  PubMed          Journal:  J Chem Neuroanat        ISSN： 0891-0618            Impact factor:   3.052


  3 in total

1.  Tryptophan metabolism in breast cancers: molecular imaging and immunohistochemistry studies.

Authors:  Csaba Juhász; Zeina Nahleh; Ian Zitron; Diane C Chugani; Majid Z Janabi; Sudeshna Bandyopadhyay; Rouba Ali-Fehmi; Thomas J Mangner; Pulak K Chakraborty; Sandeep Mittal; Otto Muzik
Journal:  Nucl Med Biol       Date:  2012-03-22       Impact factor: 2.408

Review 2.  Measuring serotonin synthesis: from conventional methods to PET tracers and their (pre)clinical implications.

Authors:  Anniek K D Visser; Aren van Waarde; Antoon T M Willemsen; Fokko J Bosker; Paul G M Luiten; Johan A den Boer; Ido P Kema; Rudi A J O Dierckx
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-11-27       Impact factor: 9.236

3.  [(11)C]5-HTP and microPET are not suitable for pharmacodynamic studies in the rodent brain.

Authors:  Anniek K D Visser; Nisha K Ramakrishnan; Antoon T M Willemsen; Valentina Di Gialleonardo; Erik F J de Vries; Ido P Kema; Rudi A J O Dierckx; Aren van Waarde
Journal:  J Cereb Blood Flow Metab       Date:  2013-10-02       Impact factor: 6.200
  3 in total

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