Literature DB >> 15246996

Antiaging treatments have been legally prescribed for approximately thirty years.

Svetlana V Ukraintseva1, Konstantin G Arbeev, Anatoly I Michalsky, Anatoly I Yashin.   

Abstract

There is an interesting divergence between the achievements of geriatrics and gerontology. On the one hand, during the last 30 years physicians in many developed countries have successfully prescribed several medicines to cure various symptoms of senescence. On the other hand, the influence of such medicines on human life span practically has not been studied. The most common of the relevant medicines are nootropic piracetam, gamma-aminobutyric acid (GABA), selegiline, Ginkgo biloba, pentoxifylline, cerebrolysin, solcoseryl, ergoloid, vinpocetin, sertraline, and estrogens, among others. Available data from human clinical practices and experimental animal studies indicate that treatments with these drugs improve learning, memory, brain metabolism, and capacity. Some of these drugs increase tolerance to various stresses such as oxygen deficit and exercise, stimulate the regeneration of neurons in the old brain, and speed up the performance of mental and physical tasks. This means that modern medicine already has "antiaging" treatments at its disposal. However, the influence of such treatments on the mean and maximal life span of humans, and on the age trajectory of a human survival curve has been poorly studied. The increase in human life expectancy at birth in the second half of the last century was mostly caused by the better survival at the old and oldest old rather than at the young ages. In parallel, the consumption of brain protective and regenerative drugs has been expanding in the elderly population. We provide evidence in support of the idea that the consumption of medicines exerting antiaging properties may contribute to the increase in human longevity.

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Year:  2004        PMID: 15246996     DOI: 10.1196/annals.1297.014

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN: 0077-8923            Impact factor:   5.691


  4 in total

1.  An inverse association between self-reported arthritis and mortality in the elderly: findings from the national long-term care survey.

Authors:  Alexander M Kulminski; Irina V Kulminskaya; Svetlana V Ukraintseva; Kenneth Land; Anatoli I Yashin
Journal:  Rejuvenation Res       Date:  2008-02       Impact factor: 4.663

2.  Effects of sertraline on executive function and quality of life in patients with advanced cancer.

Authors:  Xu-Juan Li; Zhi-Yuan Dai; Bei-Ying Zhu; Jia-Ping Zhen; Wen-Fu Yang; De-Qiang Li
Journal:  Med Sci Monit       Date:  2014-07-22

3.  Effects of cerebrolysin on nerve growth factor system in the aging rat brain.

Authors:  Mikhail Stepanichev; Mikhail Onufriev; Viktor Aniol; Sofia Freiman; Hemma Brandstaetter; Stefan Winter; Natalia Lazareva; Alla Guekht; Natalia Gulyaeva
Journal:  Restor Neurol Neurosci       Date:  2017       Impact factor: 2.406

4.  The Effects of Pentoxifylline on Serum Levels of Interleukin 10 and Interferon Gamma and Memory Function in Lipopolysaccharide-induced Inflammation in Rats.

Authors:  Hamid Reza Dehghani Dolatabadi; Mohammad Reza Zarrindast; Parham Reisi; Mohammad Nasehi
Journal:  Adv Biomed Res       Date:  2017-08-31
  4 in total

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