Literature DB >> 15246838

Differential effects of scopolamine on in vivo binding of dopamine transporter and vesicular monoamine transporter radioligands in rat brain.

Michael R Kilbourn1, Elyse S Kemmerer, Timothy J Desmond, Philip S Sherman, Kirk A Frey.   

Abstract

The in vivo equilibrium specific binding of d-threo-[3H]methylphenidate, a radioligand for the dopamine transporter (DAT), and +-alpha-[3H]dihydrotetrabenazine, a radioligand for the vesicular monoamine transporter (VMAT2), were examined in rat brain with and without prior administration of 5 mg/kg scopolamine. Drug-treated animals exhibited a 30% increase in d-threo-[3H]methylphenidate binding to the DAT in the striatum relative to controls. No changes in specific binding of +-alpha-[3H]dihydrotetrabenazine were observed in any brain region following scopolamine pretreatment. Cholinergic drugs thus differentially affect in vivo specific binding of DAT and VMAT2 radioligands, suggesting this should be a consideration in selection of in vivo markers for imaging studies of dopaminergic terminals in the brain of animals and humans.

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Year:  2004        PMID： 15246838     DOI： 10.1016/j.expneurol.2004.05.001

Source DB:  PubMed          Journal:  Exp Neurol        ISSN： 0014-4886            Impact factor:   5.330


  5 in total

1.  Locomotor activating effects of cocaine and scopolamine combinations in rats: isobolographic analysis.

Authors:  Morgane Thomsen
Journal:  Behav Pharmacol       Date:  2014-08       Impact factor: 2.293

2.  No significant effects of single intravenous, single oral and subchronic oral administration of acetylcholinesterase inhibitors on striatal [123I]FP-CIT binding in rats.

Authors:  R J J Knol; K de Bruin; B L F van Eck-Smit; J Booij
Journal:  Eur J Nucl Med Mol Imaging       Date:  2007-10-23       Impact factor: 9.236

Review 3.  Dopamine transporter imaging with [(123)I]FP-CIT SPECT: potential effects of drugs.

Authors:  Jan Booij; Paul Kemp
Journal:  Eur J Nucl Med Mol Imaging       Date:  2007-10-30       Impact factor: 9.236

4.  Methylphenidate-induced increases in vesicular dopamine sequestration and dopamine release in the striatum: the role of muscarinic and dopamine D2 receptors.

Authors:  Trent J Volz; Sarah J Farnsworth; Shane D Rowley; Glen R Hanson; Annette E Fleckenstein
Journal:  J Pharmacol Exp Ther       Date:  2008-06-30       Impact factor: 4.030

5.  Cholinesterase inhibitor use does not significantly influence the ability of 123I-FP-CIT imaging to distinguish Alzheimer's disease from dementia with Lewy bodies.

Authors:  John-Paul Taylor; Sean J Colloby; Ian G McKeith; David J Burn; David Williams; Jim Patterson; John T O'Brien
Journal:  J Neurol Neurosurg Psychiatry       Date:  2007-02-13       Impact factor: 10.154
  5 in total

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