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Literature DB >> 15246424

Linking tumor suppression, DNA damage and the anaphase-promoting complex.

Abstract

A recent study shows that the RASSF1A tumor suppressor functions as a regulator of the ordered proteolytic steps that organize mitosis. By controlling the stability of microtubules and the activity of the anaphase-promoting complex (APC), RASSF1A might provide a crucial link between mechanisms of tumor suppression and mitotic cell division. Furthermore, another recent study shows that protein kinase A, which is a key growth regulator, inhibits the APC during mitosis in yeast.

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Year: 2004 PMID： 15246424 DOI： 10.1016/j.tcb.2004.05.005

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

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Cited

11 in total

Review 1. Ubiquitin and SUMO systems in the regulation of mitotic checkpoints.

Authors: Gustavo J Gutierrez; Ze'ev Ronai
Journal: Trends Biochem Sci Date: 2006-05-02 Impact factor: 13.807

2. Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.

Authors: Julie J Miller; Matthew K Summers; David V Hansen; Maxence V Nachury; Norman L Lehman; Alex Loktev; Peter K Jackson
Journal: Genes Dev Date: 2006-08-18 Impact factor: 11.361

3. Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor.

Authors: W Liu; H Xin; D T Eckert; J A Brown; J R Gnarra
Journal: Oncogene Date: 2010-08-30 Impact factor: 9.867

4. Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis.

Authors: Asha Recino; Victoria Sherwood; Amy Flaxman; Wendy N Cooper; Farida Latif; Andrew Ward; Andrew D Chalmers
Journal: Biochem J Date: 2010-09-01 Impact factor: 3.857

9. Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships.

Authors: Kwang-Hwa Park; Sung-E Choi; Minseob Eom; Yup Kang
Journal: Breast Cancer Res Date: 2005-01-14 Impact factor: 6.466

Review 10. Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2.

Authors: Ioannis A Voutsadakis
Journal: J Cell Mol Med Date: 2007 Mar-Apr Impact factor: 5.310

Linking tumor suppression, DNA damage and the anaphase-promoting complex.

Review 1. Ubiquitin and SUMO systems in the regulation of mitotic checkpoints.

2. Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.

3. Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor.

4. Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis.

5. An in vivo study of Cdh1/APC in breast cancer formation.

6. Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis.

7. Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway.

Review 8. The Ras-association domain family (RASSF) members and their role in human tumourigenesis.

9. Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships.

Review 10. Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2.