| Literature DB >> 15246373 |
Takashi Temma1, Yasuhiro Magata, Takahiro Mukai, Haruhiro Kitano, Junji Konishi, Hideo Saji.
Abstract
Since a very complicated technique is necessary to measure cerebral blood flow (CBF) with [14C]iodoantipyrine in small animals, a practical and easy method is needed. In this paper, the differential uptake ratio (DUR) at 5 min after injection of N-isopropyl-p-[125I]iodoamphetamine (IMP) was estimated as an index of CBF in normal rats and compared with the quantitative CBF value measured using [15O]H2O and dynamic PET scan. A good correlation between the two values was obtained. The results indicate that DUR of [125I]IMP at 5 min after injection in rats is a useful and practical indicator of CBF since neither arterial blood sampling nor metabolite correction is necessary. Copyright 2004 Elsevier Inc.Entities:
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Year: 2004 PMID： 15246373 DOI： 10.1016/j.nucmedbio.2004.02.008
Source DB: PubMed Journal: Nucl Med Biol ISSN： 0969-8051 Impact factor: 2.408