Literature DB >> 15246093

Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity.

Maria T Cocco1, Cenzo Congiu, Valentina Onnis, Micaela Morelli, Vicente Felipo, Omar Cauli.   

Abstract

A new series of 2-arylamino-6-trifluoromethyl-3-carboxylic acid derivatives was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to aspirin, ibuprofen and flufenamic acid some of the new compounds exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect.

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Year:  2004        PMID： 15246093     DOI： 10.1016/j.bmc.2004.05.025

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  5 in total

1.  Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors.

Authors:  Xiao-Feng Wang; Emika Ohkoshi; Sheng-Biao Wang; Ernest Hamel; Kenneth F Bastow; Susan L Morris-Natschke; Kuo-Hsiung Lee; Lan Xie
Journal:  Bioorg Med Chem       Date:  2012-12-06       Impact factor: 3.641

2.  Synthesis and chemical and biological comparison of nitroxyl- and nitric oxide-releasing diazeniumdiolate-based aspirin derivatives.

Authors:  Debashree Basudhar; Gaurav Bharadwaj; Robert Y Cheng; Sarthak Jain; Sa Shi; Julie L Heinecke; Ryan J Holland; Lisa A Ridnour; Viviane M Caceres; Regina C Spadari-Bratfisch; Nazareno Paolocci; Carlos A Velázquez-Martínez; David A Wink; Katrina M Miranda
Journal:  J Med Chem       Date:  2013-10-08       Impact factor: 7.446

3.  O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.

Authors:  Carlos A Velázquez; P N Praveen Rao; Michael L Citro; Larry K Keefer; Edward E Knaus
Journal:  Bioorg Med Chem       Date:  2007-05-06       Impact factor: 3.641

4.  An improved solvent-free synthesis of flunixin and 2-(arylamino) nicotinic acid derivatives using boric acid as catalyst.

Authors:  Mahsa Yarhosseini; Shahrzad Javanshir; Zahra Dolatkhah; Mohammad G Dekamin
Journal:  Chem Cent J       Date:  2017-12-01       Impact factor: 4.215

5.  2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication.

Authors:  Angela Corona; Valentina Onnis; Claudia Del Vecchio; Francesca Esposito; Yung-Chi Cheng; Enzo Tramontano
Journal:  Molecules       Date:  2020-03-15       Impact factor: 4.411
  5 in total

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