| Literature DB >> 15245785 |
Valdo Ricca1, Benedetta Nacmias, Maura Boldrini, Elena Cellini, Milena di Bernardo, Claudia Ravaldi, Andrea Tedde, Silvia Bagnoli, Gian Franco Placidi, Carlo Maria Rotella, Sandro Sorbi.
Abstract
Various studies have evaluated the possible role of the -1438G/A polymorphism within the 5-HT2A receptor gene in the susceptibility to Eating Disorders (EDs). One hundred and forty-eight ED patients (EDp) and 89 control subjects were interviewed by means of the Eating Disorder Examination (EDE) and analyzed for distribution of the -1438G/A polymorphism. Patients with the AA genotype suffering from Anorexia Nervosa and Bulimia Nervosa showed higher Weight and Shape Concern (P = 0.003 and P = 0.010, respectively) scores and greater overall severity of the ED psychopathology (EDE total score) (P = 0.012). The obtained preliminary data suggest the use of dimensional psychopathological measures in ED genetic studies.Entities:
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Year: 2004 PMID： 15245785 DOI： 10.1016/j.neulet.2004.04.057
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046