| Literature DB >> 15245747 |
Graham R Stewart1, Douglas B Young.
Abstract
Heat-shock proteins (HSPs) are expressed at high levels by bacterial pathogens during adaptation to intracellular survival. Both host and pathogen heat-shock proteins contribute to immunity by receptor-mediated activation of the innate immune response and by participation in the presentation of antigens for the adaptive immune response. Manipulation of these interactions presents a potential route to improved control of infection by vaccination or immunotherapy.Entities:
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Year: 2004 PMID: 15245747 DOI: 10.1016/j.coi.2004.05.007
Source DB: PubMed Journal: Curr Opin Immunol ISSN: 0952-7915 Impact factor: 7.486