Rupture of a liposomal vesicle.

We discuss pore dynamics in osmotically stressed vesicles. A set of equations which govern the liposomal size, internal solute concentration, and pore diameter is solved numerically. We find that dependent on the internal solute concentration and vesicle size, liposomes can stay pore free, nucleate a short-lived pore, or nucleate a long-lived pore. The phase diagram of pore stability is constructed, and the different scaling regimes are deduced analytically.