BACKGROUND AND PURPOSE: The cause of spontaneous cervical artery dissection (sCAD) is largely unknown. An underlying connective tissue disorder has often been postulated, but arterial mechanical properties have rarely been studied. The study aim was to determine the elastic properties of a cervical artery, the common carotid artery, and a distal muscular artery, the radial artery in sCAD patients. METHODS: We studied 32 patients with previous sCAD (median delay: 2.2 years) and 32 control subjects with similar age and blood pressure. Internal diameter, intima-media thickness, distensibility, and Young's elastic modulus were determined at the site of the right and left common carotid arteries and the radial artery using noninvasive high-resolution echotracking systems. RESULTS: In patients with previous sCAD, cross-sectional distensibility and compliance of the affected carotid artery did not differ from those of the contralateral carotid artery. Young's elastic modulus (ie, the stiffness of the wall material) was 58% higher (0.44+/-0.32 versus 0.28+/-0.15 kPa.10(3), P<0.001) and circumferential wall stress was 14% higher (56+/-12 versus 49+/-12 kPa, P<0.001) in sCAD patients than in controls. The highest tertile of common carotid artery Young's elastic modulus was associated with an 8-fold higher risk of sCAD. Aortic stiffness, assessed from the carotid-femoral pulse wave velocity, and radial artery parameters did not differ between sCAD and controls. CONCLUSIONS: Carotid arteries, but not aorta and radial artery, displayed abnormal elastic properties in sCAD patients. Higher stiffness of carotid wall material and circumferential wall stress could increase the risk of dissection in these patients.
BACKGROUND AND PURPOSE: The cause of spontaneous cervical artery dissection (sCAD) is largely unknown. An underlying connective tissue disorder has often been postulated, but arterial mechanical properties have rarely been studied. The study aim was to determine the elastic properties of a cervical artery, the common carotid artery, and a distal muscular artery, the radial artery in sCAD patients. METHODS: We studied 32 patients with previous sCAD (median delay: 2.2 years) and 32 control subjects with similar age and blood pressure. Internal diameter, intima-media thickness, distensibility, and Young's elastic modulus were determined at the site of the right and left common carotid arteries and the radial artery using noninvasive high-resolution echotracking systems. RESULTS: In patients with previous sCAD, cross-sectional distensibility and compliance of the affected carotid artery did not differ from those of the contralateral carotid artery. Young's elastic modulus (ie, the stiffness of the wall material) was 58% higher (0.44+/-0.32 versus 0.28+/-0.15 kPa.10(3), P<0.001) and circumferential wall stress was 14% higher (56+/-12 versus 49+/-12 kPa, P<0.001) in sCAD patients than in controls. The highest tertile of common carotid artery Young's elastic modulus was associated with an 8-fold higher risk of sCAD. Aortic stiffness, assessed from the carotid-femoral pulse wave velocity, and radial artery parameters did not differ between sCAD and controls. CONCLUSIONS: Carotid arteries, but not aorta and radial artery, displayed abnormal elastic properties in sCAD patients. Higher stiffness of carotid wall material and circumferential wall stress could increase the risk of dissection in these patients.
Authors: Stéphanie Debette; Yoichiro Kamatani; Tiina M Metso; Manja Kloss; Ganesh Chauhan; Stefan T Engelter; Alessandro Pezzini; Vincent Thijs; Hugh S Markus; Martin Dichgans; Christiane Wolf; Ralf Dittrich; Emmanuel Touzé; Andrew M Southerland; Yves Samson; Shérine Abboud; Yannick Béjot; Valeria Caso; Anna Bersano; Andreas Gschwendtner; Maria Sessa; John Cole; Chantal Lamy; Elisabeth Medeiros; Simone Beretta; Leo H Bonati; Armin J Grau; Patrik Michel; Jennifer J Majersik; Pankaj Sharma; Ludmila Kalashnikova; Maria Nazarova; Larisa Dobrynina; Eva Bartels; Benoit Guillon; Evita G van den Herik; Israel Fernandez-Cadenas; Katarina Jood; Michael A Nalls; Frank-Erik De Leeuw; Christina Jern; Yu-Ching Cheng; Inge Werner; Antti J Metso; Christoph Lichy; Philippe A Lyrer; Tobias Brandt; Giorgio B Boncoraglio; Heinz-Erich Wichmann; Christian Gieger; Andrew D Johnson; Thomas Böttcher; Maurizio Castellano; Dominique Arveiler; M Arfan Ikram; Monique M B Breteler; Alessandro Padovani; James F Meschia; Gregor Kuhlenbäumer; Arndt Rolfs; Bradford B Worrall; Erich-Bernd Ringelstein; Diana Zelenika; Turgut Tatlisumak; Mark Lathrop; Didier Leys; Philippe Amouyel; Jean Dallongeville Journal: Nat Genet Date: 2014-11-24 Impact factor: 38.330
Authors: Tiina M Metso; Stéphanie Debette; Caspar Grond-Ginsbach; Stefan T Engelter; Didier Leys; Tobias Brandt; Alessandro Pezzini; Anna Bersano; Manja Kloss; Vincent Thijs; Philippe A Lyrer; Turgut Tatlisumak; Antti J Metso Journal: J Neurol Date: 2012-04-18 Impact factor: 4.849
Authors: Fahad F Al-Mutairi; Abtehal Al-Hussaini; David Adlam; Emma M L Chung; Kumar V Ramnarine; Anne-Marie Marsh; Nilesh Samani; Gerry McCann Journal: J Ultrasound Date: 2022-01-15