Michael Fleming1, Marlon Mundt. 1. Department of Family Medicine, University of Wisconsin Medical School, Madison, 53715, USA. mfleming@fammed.wisc.edu
Abstract
OBJECTIVE: To test the reliability and validity of a new alcohol biomarker. DESIGN: Cross-sectional with matched control. Alcohol use, symptoms of alcohol dependence, health status, current medications, carbohydrate-deficient transferrin (CDT) levels, and gamma-glutamyl transferase levels were assessed. Validity of the %CDT test was estimated using a drinking cutoff of 90 or more drinks in the previous 30 days. PARTICIPANTS: Sample (n = 799) included 89 patients with type 2 diabetes, 299 patients with hypertension, 209 patients with hypertension and type 2 diabetes, and 202 matched control subjects with neither diabetes nor hypertension. RESULTS: Three hundred ninety-six women and 403 men ages 30 to 60 participated in the study. Six percent (45 of 799) reported drinking more than 14 drinks per week, 2% (n = 17) met criteria for alcohol abuse, and 3% (n = 23) met DSM-IV criteria for dependence. The overall sensitivity of the %CDT test was 61% with a specificity of 85%. A receiver operating characteristic curve was used to determine that the best fit was for persons who reported >90 drinks per month and a CDT level >2.5% with an area under the curve of 0.83. Test-retest reliability (R) was 0.94. CONCLUSIONS: %CDT levels are useful in detecting and/or confirming high-risk drinking in patients being treated for type 2 diabetes and hypertension.
OBJECTIVE: To test the reliability and validity of a new alcohol biomarker. DESIGN: Cross-sectional with matched control. Alcohol use, symptoms of alcohol dependence, health status, current medications, carbohydrate-deficient transferrin (CDT) levels, and gamma-glutamyl transferase levels were assessed. Validity of the %CDT test was estimated using a drinking cutoff of 90 or more drinks in the previous 30 days. PARTICIPANTS: Sample (n = 799) included 89 patients with type 2 diabetes, 299 patients with hypertension, 209 patients with hypertension and type 2 diabetes, and 202 matched control subjects with neither diabetes nor hypertension. RESULTS: Three hundred ninety-six women and 403 men ages 30 to 60 participated in the study. Six percent (45 of 799) reported drinking more than 14 drinks per week, 2% (n = 17) met criteria for alcohol abuse, and 3% (n = 23) met DSM-IV criteria for dependence. The overall sensitivity of the %CDT test was 61% with a specificity of 85%. A receiver operating characteristic curve was used to determine that the best fit was for persons who reported >90 drinks per month and a CDT level >2.5% with an area under the curve of 0.83. Test-retest reliability (R) was 0.94. CONCLUSIONS: %CDT levels are useful in detecting and/or confirming high-risk drinking in patients being treated for type 2 diabetes and hypertension.
Authors: Raymond F Anton; Raye Z Litten; Daniel E Falk; Joseph M Palumbo; Raymond T Bartus; Rebecca L Robinson; Henry R Kranzler; Thomas R Kosten; Roger E Meyer; Charles P O'Brien; Karl Mann; Didier Meulien Journal: Neuropsychopharmacology Date: 2011-09-07 Impact factor: 7.853
Authors: Susan E Ramsey; Patricia A Engler; Magdalena Harrington; Robert J Smith; Mark J Fagan; Michael D Stein; Peter Friedmann Journal: Subst Abuse Date: 2010-01-01
Authors: Peter M Miller; Raymond F Anton; Brent M Egan; Jan Basile; Shaun A Nguyen Journal: J Clin Hypertens (Greenwich) Date: 2005-06 Impact factor: 3.738
Authors: Kevin M Pantalone; Anita D Misra-Hebert; Todd M Hobbs; Sheldon X Kong; Xinge Ji; Rahul Ganguly; Alex Milinovich; Wayne Weng; Janine M Bauman; Paul Petraro; Bartolome Burguera; Robert S Zimmerman; Michael W Kattan Journal: Diabetes Care Date: 2020-06-11 Impact factor: 19.112
Authors: Ranjani Ganapathy S; Kateřina Levová; Lenka Kotačková; Jiří Trnka; David Zogala; Jan Rusz; Tomáš Zima; David Devos; Karel Šonka; Evžen Růžička; Marta Kalousová; Petr Dušek Journal: Mov Disord Date: 2022-02-07 Impact factor: 9.698