Literature DB >> 15242965

Long-term effects of immunization with recombinant lipoprotein outer surface protein a on serologic test for lyme disease.

Paul T Fawcett1, Carlos D Rose, Victoria Maduskuie.   

Abstract

Immunization with recombinant lipoprotein outer surface protein A vaccine is known to interfere with some serologic tests for Lyme disease. We tested sera from 152 vaccine recipients by using in-house and commercial Western blot assays and found that vaccination caused interference in up to 25% of recipients and can persist for over 6 years.

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Year:  2004        PMID： 15242965      PMCID： PMC440630          DOI： 10.1128/CDLI.11.4.808-810.2004

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  6 in total

1.  Effects of OspA vaccination on Lyme disease serologic testing.

Authors:  M E Aguero-Rosenfeld; J Roberge; C A Carbonaro; J Nowakowski; R B Nadelman; G P Wormser
Journal:  J Clin Microbiol       Date:  1999-11       Impact factor: 5.948

2.  Frequency and specificity of antibodies that crossreact with Borrelia burgdorferi antigens.

Authors:  P T Fawcett; K M Gibney; C D Rose; S B Dubbs; R A Doughty
Journal:  J Rheumatol       Date:  1992-04       Impact factor: 4.666

3.  Recommendations for test performance and interpretation from the Second National Conference on Serologic Diagnosis of Lyme Disease.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  1995-08-11       Impact factor: 17.586

4.  Effect of immunization with recombinant OspA on serologic tests for Lyme borreliosis.

Authors:  P T Fawcett; C D Rose; S M Budd; K M Gibney
Journal:  Clin Diagn Lab Immunol       Date:  2001-01

5.  Detection of multiple reactive protein species by immunoblotting after recombinant outer surface protein A lyme disease vaccination.

Authors:  P J Molloy; V P Berardi; D H Persing; L H Sigal
Journal:  Clin Infect Dis       Date:  2000-07-17       Impact factor: 9.079

6.  Comparative evaluation of adsorption with E. coli on ELISA tests for Lyme borreliosis.

Authors:  P T Fawcett; C D Rose; K M Gibney
Journal:  J Rheumatol       Date:  1995-04       Impact factor: 4.666
  6 in total
  2 in total

1.  Evaluation of the recombinant VlsE-based liaison chemiluminescence immunoassay for detection of Borrelia burgdorferi and diagnosis of Lyme disease.

Authors:  Thomas B Ledue; Marilyn F Collins; John Young; Martin E Schriefer
Journal:  Clin Vaccine Immunol       Date:  2008-10-22

2.  Detection of immune complexes is not independent of detection of antibodies in Lyme disease patients and does not confirm active infection with Borrelia burgdorferi.

Authors:  Adriana R Marques; Ronald L Hornung; Len Dally; Mario T Philipp
Journal:  Clin Diagn Lab Immunol       Date:  2005-09
  2 in total

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