| Literature DB >> 15242639 |
Abstract
Huntington's disease is a progressive autosomal dominant neurodegenerative disorder caused by expansion of a CAG repeat coding for polyglutamine in the huntingtin protein. A recent report suggests a new mechanism involving altered interactions with a protein involved in axonal transport, leading to loss of neurotrophic factor transport. This suggests an intriguing convergence to previously described pathways implicating neurotrophin transcription in HD pathogenesis.Entities:
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Year: 2004 PMID： 15242639 DOI： 10.1016/j.cell.2004.06.022
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582