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Literature DB >> 15242638

Neddylating the guardian; Mdm2 catalyzed conjugation of Nedd8 to p53.

Abstract

The tumor suppressor and transcriptional regulator p53 is perhaps one of the most regulated proteins in the cell nucleus and is acted upon by a variety of protein kinases, acetylases, ubiqutin ligases and hydrolases, and SUMO-conjugating enzymes. Now new work suggests a role for an additional modification-neddylation-in negative regulation of p53 transcriptional activity.

Entities: Disease Gene

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Year: 2004 PMID： 15242638 DOI： 10.1016/j.cell.2004.06.015

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

10 in total

Review 1. Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy.

Authors: Tomoaki Tanaka; Tatsuya Nakatani; Tetsu Kamitani
Journal: Mol Oncol Date: 2012-01-21 Impact factor: 6.603

2. Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system.

Authors: Rajesh K Singh; Sylvia Zerath; Oded Kleifeld; Martin Scheffner; Michael H Glickman; David Fushman
Journal: Mol Cell Proteomics Date: 2012-10-26 Impact factor: 5.911

Review 3. The role of ubiquitination in tumorigenesis and targeted drug discovery.

Authors: Lu Deng; Tong Meng; Lei Chen; Wenyi Wei; Ping Wang
Journal: Signal Transduct Target Ther Date: 2020-02-29

4. Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3.

Authors: Noriko Yoneda-Kato; Kiichiro Tomoda; Mari Umehara; Yukinobu Arata; Jun-ya Kato
Journal: EMBO J Date: 2005-04-21 Impact factor: 11.598

5. Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts.

Authors: Xinwen Yang; Jianhua Wang; Cunren Liu; William E Grizzle; Shaohua Yu; Shuangqin Zhang; Stephen Barnes; William J Koopman; John D Mountz; Robert P Kimberly; Huang-Ge Zhang
Journal: Am J Pathol Date: 2005-09 Impact factor: 4.307

6. SHANK1 facilitates non-small cell lung cancer processes through modulating the ubiquitination of Klotho by interacting with MDM2.

Authors: Bo Chen; Hongye Zhao; Min Li; Quan She; Wen Liu; Jiayi Zhang; Weihong Zhao; Shuhong Huang; Jianqing Wu
Journal: Cell Death Dis Date: 2022-04-25 Impact factor: 9.685

Neddylating the guardian; Mdm2 catalyzed conjugation of Nedd8 to p53.

Review 1. Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy.

2. Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system.

Review 3. The role of ubiquitination in tumorigenesis and targeted drug discovery.

4. Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3.

5. Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts.

6. SHANK1 facilitates non-small cell lung cancer processes through modulating the ubiquitination of Klotho by interacting with MDM2.

7. Neddylation of PTEN regulates its nuclear import and promotes tumor development.

8. Prediction of neddylation sites from protein sequences and sequence-derived properties.

9. Small molecules targeting the NEDD8·NAE protein-protein interaction.

Review 10. The role of ubiquitination in tumorigenesis and targeted drug discovery.